DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_SCF_TRCP1_1

Location: 764:769

E3 ligase: BTRC

DEGRON score: 0.7405

ASA_SCORE: 77.2833

COIL: 0.7895

CONS_SCORE: 0.5817

DSS_SCORE: 0.2682

HELIX: 0.101

FCONS_SCORE: 0.7913

RIG_SCORE: 0.691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L754I	TCGA-2W-A8YY	CESC	TCGA	DSGNLS	DEG_SCF_TRCP1_1	0.0556
p.L754I	DO223732	CESC	ICGC	DSGNLS	DEG_SCF_TRCP1_1	0.0556
p.D779N	TCGA-A5-A1OF	UCEC	TCGA	DSGNLS	DEG_SCF_TRCP1_1	0.0556
p.D779N	DO42568	UCEC	ICGC	DSGNLS	DEG_SCF_TRCP1_1	0.0556
p.R755Q	TCGA-CA-6717	COAD	TCGA	DSGNLS	DEG_SCF_TRCP1_1	0.0833
p.R755Q	DO8264	COAD	ICGC	DSGNLS	DEG_SCF_TRCP1_1	0.0833
p.R755Q	ACH-001664	Gastric Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	0.0833
p.N767K	DO46372	OV	ICGC	DSGNLS	DEG_SCF_TRCP1_1	0.5806
p.D765Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	0.7325
p.Q778E	ACH-001411	Bladder Cancer	CCLE	DSGNLS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DQ2	Very large A-kinase anchor protein	DEG_SCF_TRCP1_1	764:769	DSGNLS	BTRC	0.7405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons