DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_APCC_KENBOX_2

Location: 312:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9696

ASA_SCORE: 105.38

COIL: 0.7912

CONS_SCORE: 0.589

DSS_SCORE: 0.5536

HELIX: 0.1396

FCONS_SCORE: 1.1357

RIG_SCORE: 0.699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S324I	TCGA-55-8204	LUAD	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1111
p.S324I	DO45322	LUAD	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1111
p.G308V	TCGA-66-2795	LUSC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.3333
p.G308V	DO26710	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.3333
p.D303E	TCGA-EO-A22R	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.0833
p.D303E	DO42713	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S316Y	TCGA-EO-A22X	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.6009
p.S316Y	DO43907	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.6009
p.S316Y	ACH-001991	Primary	CCLE	NKENS	DEG_APCC_KENBOX_2	0.6009
p.P314L	TCGA-OR-A5JJ	ACC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.7582
p.Q324K	DO233625	GACA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1111
p.R320H	DO23176	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.G304R	ACH-000988	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MG5	Microtubule-associated protein 9	DEG_APCC_KENBOX_2	285:289	NKENS	APC,CDC20,FZR1	0.9917	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_APCC_KENBOX_2	952:956	NKENS	APC,CDC20,FZR1	0.9585	More...
Q5TAX3	Terminal uridylyltransferase 4	DEG_APCC_KENBOX_2	248:252	NKENS	APC,CDC20,FZR1	0.8891	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	312:316	NKENS	APC,CDC20,FZR1	0.9696	More...
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_APCC_KENBOX_2	77:81	NKENS	APC,CDC20,FZR1	0.9762	More...
Q64ET8	Protein FRG2	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.8608	More...
A6NGY1	Protein FRG2-like-2	DEG_APCC_KENBOX_2	67:71	NKENS	APC,CDC20,FZR1	0.969	More...
C9J7I0	UBAP1-MVB12-associated	DEG_APCC_KENBOX_2	54:58	NKENS	APC,CDC20,FZR1	0.9985	More...
Q96QU4	Protein FRG2-like-1	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons