DegronMD - Q49MG5(MAP9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S7I	TCGA-A5-A0G1	UCEC	TCGA	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.8453
p.S7I	DO42472	UCEC	ICGC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.8453
p.N278S	TCGA-A5-A0GV	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation rewiring degron network	0.1389
p.N278S	DO42641	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation rewiring degron network	0.1389
p.E287D	TCGA-AP-A1E0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.6758
p.E287D	TCGA-FI-A2D5	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.6758
p.E287D	DO43154	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.6758
p.E287D	DO41331	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.6758
p.S386F	TCGA-BR-8679	STAD	TCGA	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.S386F	DO47875	STAD	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.E275D	TCGA-BR-8680	STAD	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation rewiring degron network	0.0556
p.E275D	DO47769	STAD	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation rewiring degron network	0.0556
p.G401R	TCGA-CK-5913	COAD	TCGA	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.G401R	DO8826	COAD	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.S289L	TCGA-CV-7568	HNSC	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.7667
p.S289L	DO14160	HNSC	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.7667
p.K404N	TCGA-EA-A43B	CESC	TCGA	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.1944
p.K404N	DO44384	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.1944
p.K281E	TCGA-EO-A3B0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation substituting flanking lysine	0.3333
p.K281E	DO219773	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation substituting flanking lysine	0.3333
p.A11T	TCGA-FI-A2D5	UCEC	TCGA	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.A11T	DO41331	UCEC	ICGC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.S385G	TCGA-UF-A71D	HNSC	TCGA	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation blocking phosphorylation signal	0.6111
p.S385G	DO52109	HNSC	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation blocking phosphorylation signal	0.6111
p.S397F	DO220823	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation blocking phosphorylation signal	0.7222
p.R389G	DO230311	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2778
p.P16A	DO50968	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1389
p.P391L	DO222749	MELA	ICGC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.7582
p.T296I	DO232761	PBCA	ICGC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation rewiring degron network	0.1389
p.D3H	SIDM00697	Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.D3H	SIDM00340	Plasma Cell Myeloma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.D3H	SIDM00620	Glioblastoma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.D3H	SIDM00648	Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.D3H	SIDM00832	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.D3H	SIDM00854	Burkitt's Lymphoma	GDSC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.K382N	SIDM00118	Colorectal Carcinoma	GDSC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.1944
p.K382N	ACH-001081	Colon/Colorectal Cancer	CCLE	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.1944
p.K382N	HCC2998	large intestine	COSMIC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.1944
p.L381M	SIDM00720	Mesothelioma	GDSC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0556
p.L381M	SIDM01409	Bladder Carcinoma	GDSC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0556
p.L381M	NCI-H28	pleura	COSMIC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0556
p.D287G	SU-DHL-8	NS	COSMIC	NKENS	DEG_APCC_KENBOX_2	285:289	Mutation altering degron motif	0.7198
p.I6T	NCI-H128	lung	COSMIC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7078
p.D9Y	KYSE-150	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7325
p.Q388L	NCI-SNU-5	stomach	COSMIC	PSTTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP9

UniProt ID: Q49MG5

Entrez ID: 79884

Protein name: Microtubule-associated protein 9 (Aster-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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