DegronMD

Uniprot ID: Q49MG5

Source protein: Microtubule-associated protein 9

Source gene: MAP9

Class: DEG_APCC_KENBOX_2

Location: 285:289

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 109.14

COIL: 0.742

CONS_SCORE: 0.4706

DSS_SCORE: 0.6431

HELIX: 0.2286

FCONS_SCORE: 0.9941

RIG_SCORE: 0.6148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N278S	TCGA-A5-A0GV	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1389
p.N278S	DO42641	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.E287D	TCGA-AP-A1E0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E287D	TCGA-FI-A2D5	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E287D	DO43154	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E287D	DO41331	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E275D	TCGA-BR-8680	STAD	TCGA	NKENS	DEG_APCC_KENBOX_2	0.0556
p.E275D	DO47769	STAD	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0556
p.S289L	TCGA-CV-7568	HNSC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.7667
p.S289L	DO14160	HNSC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.7667
p.K281E	TCGA-EO-A3B0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.3333
p.K281E	DO219773	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.3333
p.T296I	DO232761	PBCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.D287G	SU-DHL-8	NS	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MG5	Microtubule-associated protein 9	DEG_APCC_KENBOX_2	285:289	NKENS	APC,CDC20,FZR1	0.9917	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_APCC_KENBOX_2	952:956	NKENS	APC,CDC20,FZR1	0.9585	More...
Q5TAX3	Terminal uridylyltransferase 4	DEG_APCC_KENBOX_2	248:252	NKENS	APC,CDC20,FZR1	0.8891	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	312:316	NKENS	APC,CDC20,FZR1	0.9696	More...
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_APCC_KENBOX_2	77:81	NKENS	APC,CDC20,FZR1	0.9762	More...
Q64ET8	Protein FRG2	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.8608	More...
A6NGY1	Protein FRG2-like-2	DEG_APCC_KENBOX_2	67:71	NKENS	APC,CDC20,FZR1	0.969	More...
C9J7I0	UBAP1-MVB12-associated	DEG_APCC_KENBOX_2	54:58	NKENS	APC,CDC20,FZR1	0.9985	More...
Q96QU4	Protein FRG2-like-1	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons