DegronMD

Uniprot ID: Q5SYB0

Source protein: FERM and PDZ domain-containing protein 1

Source gene: FRMPD1

Class: DEG_APCC_KENBOX_2

Location: 952:956

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9585

ASA_SCORE: 108.42

COIL: 0.9334

CONS_SCORE: 0.4289

DSS_SCORE: 0.4993

HELIX: 0.0482

FCONS_SCORE: 0.9816

RIG_SCORE: 0.6317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R947Q	TCGA-AA-3821	COAD	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1944
p.R947Q	DO9314	COAD	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.R947Q	SIDM01494	Glioblastoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.R947Q	ACH-000445	Brain Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	0.1944
p.R945H	TCGA-AA-3984	COAD	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	TCGA-AP-A1DV	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	TCGA-EO-A3B0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	DO222693	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	DO222905	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	DO9002	COAD	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	DO219773	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945H	DO43186	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.E954D	TCGA-F5-6814	READ	TCGA	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E954D	DO36556	READ	ICGC	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E954D	SIDM01611	Endometrial Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.6758
p.E954D	ACH-000996	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	0.6758
p.R947W	DO223061	ESCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.P960H	DO233855	GACA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.R945L	DO229015	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.V959F	DO229045	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.25
p.R945C	SIDM00234	Other Solid Cancers	GDSC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945C	SIDM01588	Endometrial Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945C	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945C	ACH-002201	Cervical Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	0.1389
p.R945C	TC-YIK	cervix	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MG5	Microtubule-associated protein 9	DEG_APCC_KENBOX_2	285:289	NKENS	APC,CDC20,FZR1	0.9917	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_APCC_KENBOX_2	952:956	NKENS	APC,CDC20,FZR1	0.9585	More...
Q5TAX3	Terminal uridylyltransferase 4	DEG_APCC_KENBOX_2	248:252	NKENS	APC,CDC20,FZR1	0.8891	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	312:316	NKENS	APC,CDC20,FZR1	0.9696	More...
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_APCC_KENBOX_2	77:81	NKENS	APC,CDC20,FZR1	0.9762	More...
Q64ET8	Protein FRG2	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.8608	More...
A6NGY1	Protein FRG2-like-2	DEG_APCC_KENBOX_2	67:71	NKENS	APC,CDC20,FZR1	0.969	More...
C9J7I0	UBAP1-MVB12-associated	DEG_APCC_KENBOX_2	54:58	NKENS	APC,CDC20,FZR1	0.9985	More...
Q96QU4	Protein FRG2-like-1	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENS

Degron related mutations and impact score

Drug responses associated with FRMPD1 mutations

All proteins holding degron of NKENS