DegronMD - Q9ULD4(BRPF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1146H	TCGA-44-2657	LUAD	TCGA	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1667
p.E73K	TCGA-AG-A002	READ	TCGA	NKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.2222
p.R1143H	TCGA-AZ-4614	COAD	TCGA	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.25
p.A1129T	TCGA-B5-A11E	UCEC	TCGA	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1667
p.N902S	TCGA-BH-A0H3	BRCA	TCGA	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.0556
p.N902S	DO3239	BRCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.0556
p.N902S	SIDM00277	Acute Myeloid Leukemia	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.0556
p.N902S	ACH-000198	Leukemia	CCLE	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.0556
p.N902S	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.0556
p.K91N	TCGA-BS-A0UV	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	77:81	Mutation substituting flanking lysine	0.1667
p.K91N	DO42793	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	77:81	Mutation substituting flanking lysine	0.1667
p.R925H	TCGA-DM-A28K	COAD	TCGA	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1389
p.R925H	DO8167	COAD	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1389
p.V923L	TCGA-EO-A22U	UCEC	TCGA	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1944
p.V923L	DO43755	UCEC	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1944
p.R906K	TCGA-GC-A4ZW	BLCA	TCGA	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1667
p.R906K	DO219024	BLCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.1667
p.L1135I	TCGA-GN-A26D	SKCM	TCGA	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation altering degron motif	0.6063
p.E1128K	TCGA-GU-AATP	BLCA	TCGA	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.A916V	DO8192	COAD	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5825
p.A916V	DO228138	PBCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5825
p.P915L	DO233259	GACA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.7582
p.V909L	DO18114	KIRC	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.25
p.P912S	DO228224	LICA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.6752
p.A68S	DO229029	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	77:81	Mutation rewiring degron network	0.0833
p.G917S	SIDM00185	Melanoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	SIDM01650	Non-Cancerous	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	SIDM01111	Ewing's Sarcoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	ACH-000087	Bone Cancer	CCLE	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	ACH-000106	Lymphoma	CCLE	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.G917S	ACH-002354	Non-Cancerous	CCLE	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation altering degron motif	0.5882
p.R1150K	SIDM00007	Other Solid Cancers	GDSC	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.0556
p.R1150K	ACH-001550	Skin Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.0556
p.L909F	SIDM00103	Mesothelioma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.25
p.L909F	ACH-002124	Lung Cancer	CCLE	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.25
p.L909F	H2373	pleura	COSMIC	PDTPAGT	DEG_SCF_FBW7_1	912:918	Mutation rewiring degron network	0.25
p.E1128Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.E1128Q	SIDM01757	Bladder Carcinoma	GDSC	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.E1128Q	ACH-000741	Bladder Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.E1128Q	ACH-000875	Lung Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.E1128Q	NCI-H2347	lung	COSMIC	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.1389
p.T1144A	ACH-000986	Colon/Colorectal Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.2222
p.T1144A	HT-115	large intestine	COSMIC	LVLFFD	LIG_APCC_ABBA_1	1135:1140	Mutation rewiring degron network	0.2222

Kaplan plot for BRPF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRPF3

UniProt ID: Q9ULD4

Entrez ID: 27154

Protein name: Bromodomain and PHD finger-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRPF3 in