DegronMD

Uniprot ID: Q9ULD4

Source protein: Bromodomain and PHD finger-containing protein 3

Source gene: BRPF3

Class: LIG_APCC_ABBA_1

Location: 1135:1140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5954

ASA_SCORE: 16.95

COIL: 0.1713

CONS_SCORE: 0.4426

DSS_SCORE: 0.0551

HELIX: 0.005

FCONS_SCORE: 1.2596

RIG_SCORE: 0.9716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1146H	TCGA-44-2657	LUAD	TCGA	LVLFFD	LIG_APCC_ABBA_1	0.1667
p.R1143H	TCGA-AZ-4614	COAD	TCGA	LVLFFD	LIG_APCC_ABBA_1	0.25
p.A1129T	TCGA-B5-A11E	UCEC	TCGA	LVLFFD	LIG_APCC_ABBA_1	0.1667
p.L1135I	TCGA-GN-A26D	SKCM	TCGA	LVLFFD	LIG_APCC_ABBA_1	0.6063
p.E1128K	TCGA-GU-AATP	BLCA	TCGA	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.R1150K	SIDM00007	Other Solid Cancers	GDSC	LVLFFD	LIG_APCC_ABBA_1	0.0556
p.R1150K	ACH-001550	Skin Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	0.0556
p.E1128Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.E1128Q	SIDM01757	Bladder Carcinoma	GDSC	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.E1128Q	ACH-000741	Bladder Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.E1128Q	ACH-000875	Lung Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.E1128Q	NCI-H2347	lung	COSMIC	LVLFFD	LIG_APCC_ABBA_1	0.1389
p.T1144A	ACH-000986	Colon/Colorectal Cancer	CCLE	LVLFFD	LIG_APCC_ABBA_1	0.2222
p.T1144A	HT-115	large_intestine	COSMIC	LVLFFD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD4	Bromodomain and PHD finger-containing protein 3	LIG_APCC_ABBA_1	1135:1140	LVLFFD	APC,CDC20,FZR1	0.5954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons