DegronMD

Uniprot ID: Q9ULD4

Source protein: Bromodomain and PHD finger-containing protein 3

Source gene: BRPF3

Class: DEG_SCF_FBW7_1

Location: 912:918

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 74.9571

COIL: 0.9573

CONS_SCORE: 0.2947

DSS_SCORE: 0.4961

HELIX: 0.0231

FCONS_SCORE: 0.8952

RIG_SCORE: 0.666

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P915L	DO233259	GACA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.7582
p.P912S	DO228224	LICA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.6752
p.G917S	SIDM00185	Melanoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	SIDM01650	Non-Cancerous	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	SIDM01111	Ewing's Sarcoma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	ACH-000087	Bone Cancer	CCLE	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	ACH-000106	Lymphoma	CCLE	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.G917S	ACH-002354	Non-Cancerous	CCLE	PDTPAGT	DEG_SCF_FBW7_1	0.5882
p.A916V	DO8192	COAD	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.5825
p.A916V	DO228138	PBCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.5825
p.V909L	DO18114	KIRC	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.25
p.L909F	SIDM00103	Mesothelioma	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.25
p.L909F	ACH-002124	Lung Cancer	CCLE	PDTPAGT	DEG_SCF_FBW7_1	0.25
p.L909F	H2373	pleura	COSMIC	PDTPAGT	DEG_SCF_FBW7_1	0.25
p.V923L	TCGA-EO-A22U	UCEC	TCGA	PDTPAGT	DEG_SCF_FBW7_1	0.1944
p.V923L	DO43755	UCEC	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.1944
p.R906K	TCGA-GC-A4ZW	BLCA	TCGA	PDTPAGT	DEG_SCF_FBW7_1	0.1667
p.R906K	DO219024	BLCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.1667
p.R925H	TCGA-DM-A28K	COAD	TCGA	PDTPAGT	DEG_SCF_FBW7_1	0.1389
p.R925H	DO8167	COAD	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.1389
p.N902S	TCGA-BH-A0H3	BRCA	TCGA	PDTPAGT	DEG_SCF_FBW7_1	0.0556
p.N902S	DO3239	BRCA	ICGC	PDTPAGT	DEG_SCF_FBW7_1	0.0556
p.N902S	SIDM00277	Acute Myeloid Leukemia	GDSC	PDTPAGT	DEG_SCF_FBW7_1	0.0556
p.N902S	ACH-000198	Leukemia	CCLE	PDTPAGT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 25 of 26 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_SCF_FBW7_1	912:918	PDTPAGT	FBXW7	0.9991	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons