DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NKENS
Uniprot ID:
C9J7I0
Source protein:
UBAP1-MVB12-associated
Source gene:
UMAD1
Class:
DEG_APCC_KENBOX_2
Location:
54:58
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9985
ASA_SCORE:
110.12
COIL:
0.9092
CONS_SCORE:
0.8292
DSS_SCORE:
0.6845
HELIX:
0.0638
FCONS_SCORE:
1.6617
RIG_SCORE:
0.6092
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with UMAD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKENS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q49MG5
Microtubule-associated protein 9
DEG_APCC_KENBOX_2
285:289
NKENS
APC,CDC20,FZR1
0.9917
More...
Q5SYB0
FERM and PDZ domain-containing protein 1
DEG_APCC_KENBOX_2
952:956
NKENS
APC,CDC20,FZR1
0.9585
More...
Q5TAX3
Terminal uridylyltransferase 4
DEG_APCC_KENBOX_2
248:252
NKENS
APC,CDC20,FZR1
0.8891
More...
Q68DQ2
Very large A-kinase anchor protein
DEG_APCC_KENBOX_2
312:316
NKENS
APC,CDC20,FZR1
0.9696
More...
Q9ULD4
Bromodomain and PHD finger-containing protein 3
DEG_APCC_KENBOX_2
77:81
NKENS
APC,CDC20,FZR1
0.9762
More...
Q64ET8
Protein FRG2
DEG_APCC_KENBOX_2
66:70
NKENS
APC,CDC20,FZR1
0.8608
More...
A6NGY1
Protein FRG2-like-2
DEG_APCC_KENBOX_2
67:71
NKENS
APC,CDC20,FZR1
0.969
More...
C9J7I0
UBAP1-MVB12-associated
DEG_APCC_KENBOX_2
54:58
NKENS
APC,CDC20,FZR1
0.9985
More...
Q96QU4
Protein FRG2-like-1
DEG_APCC_KENBOX_2
66:70
NKENS
APC,CDC20,FZR1
0.9317
More...