DegronMD

Uniprot ID: Q64ET8

Source protein: Protein FRG2

Source gene: FRG2

Class: DEG_APCC_KENBOX_2

Location: 66:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8608

ASA_SCORE: 105

COIL: 0.7126

CONS_SCORE: 0.5588

DSS_SCORE: 0.7924

HELIX: 0.2712

FCONS_SCORE: 1.1892

RIG_SCORE: 0.5643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S62W	DO225265	BRCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.S62W	DO228186	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.S62W	DO228672	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.S62W	DO52357	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.S62W	DO229250	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.2222
p.G79W	DO229218	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MG5	Microtubule-associated protein 9	DEG_APCC_KENBOX_2	285:289	NKENS	APC,CDC20,FZR1	0.9917	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_APCC_KENBOX_2	952:956	NKENS	APC,CDC20,FZR1	0.9585	More...
Q5TAX3	Terminal uridylyltransferase 4	DEG_APCC_KENBOX_2	248:252	NKENS	APC,CDC20,FZR1	0.8891	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	312:316	NKENS	APC,CDC20,FZR1	0.9696	More...
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_APCC_KENBOX_2	77:81	NKENS	APC,CDC20,FZR1	0.9762	More...
Q64ET8	Protein FRG2	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.8608	More...
A6NGY1	Protein FRG2-like-2	DEG_APCC_KENBOX_2	67:71	NKENS	APC,CDC20,FZR1	0.969	More...
C9J7I0	UBAP1-MVB12-associated	DEG_APCC_KENBOX_2	54:58	NKENS	APC,CDC20,FZR1	0.9985	More...
Q96QU4	Protein FRG2-like-1	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons