DegronMD

Uniprot ID: A6NGY1

Source protein: Protein FRG2-like-2

Source gene: FRG2C

Class: DEG_APCC_KENBOX_2

Location: 67:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.969

ASA_SCORE: 104.04

COIL: 0.7538

CONS_SCORE: 0.4936

DSS_SCORE: 0.7947

HELIX: 0.2262

FCONS_SCORE: 1.2465

RIG_SCORE: 0.5675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S80R	DO222669	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO222782	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO222788	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO222733	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO222816	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO23208	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO23420	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO52389	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.S80R	DO229087	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.D62E	DO222553	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO222785	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO222782	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO222715	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO222888	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO228905	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO228976	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO229045	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.D62E	DO229057	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	0.1944
p.K77M	SIDM00683	Prostate Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.2778
p.R58S	SIDM00731	Small Cell Lung Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.R58S	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.R58S	NCI-H2196	lung	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.R58S	NCI-H522	lung	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.0833
p.A78S	KP-1N	pancreas	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.1389
p.A77S	KP-1N	pancreas	COSMIC	NKENS	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q49MG5	Microtubule-associated protein 9	DEG_APCC_KENBOX_2	285:289	NKENS	APC,CDC20,FZR1	0.9917	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_APCC_KENBOX_2	952:956	NKENS	APC,CDC20,FZR1	0.9585	More...
Q5TAX3	Terminal uridylyltransferase 4	DEG_APCC_KENBOX_2	248:252	NKENS	APC,CDC20,FZR1	0.8891	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	312:316	NKENS	APC,CDC20,FZR1	0.9696	More...
Q9ULD4	Bromodomain and PHD finger-containing protein 3	DEG_APCC_KENBOX_2	77:81	NKENS	APC,CDC20,FZR1	0.9762	More...
Q64ET8	Protein FRG2	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.8608	More...
A6NGY1	Protein FRG2-like-2	DEG_APCC_KENBOX_2	67:71	NKENS	APC,CDC20,FZR1	0.969	More...
C9J7I0	UBAP1-MVB12-associated	DEG_APCC_KENBOX_2	54:58	NKENS	APC,CDC20,FZR1	0.9985	More...
Q96QU4	Protein FRG2-like-1	DEG_APCC_KENBOX_2	66:70	NKENS	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons