DegronMD - A6NGY1(FRG2C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S80R	DO222669	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO222669	BTCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO222782	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO222782	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO222788	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO222788	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO222733	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO222733	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO222816	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO222816	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO23208	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO23208	LINC	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO23420	LINC	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO23420	LINC	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO52389	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO52389	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S80R	DO229087	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S80R	DO229087	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.E93K	DO222834	BTCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.G83R	DO222476	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.G83R	DO229006	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.D62E	DO222553	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO222785	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO222782	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO222715	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO222888	COCA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO228905	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO228976	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO229045	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.D62E	DO229057	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1944
p.Q92R	DO229024	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.K77M	SIDM00683	Prostate Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation substituting flanking lysine	0.2778
p.K77M	SIDM00683	Prostate Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation substituting flanking lysine	0.1667
p.S85L	SIDM01265	Plasma Cell Myeloma	GDSC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S85L	MM1S	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.R58S	SIDM00731	Small Cell Lung Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.R58S	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.R58S	NCI-H2196	lung	COSMIC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.R58S	NCI-H522	lung	COSMIC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.0833
p.S90T	NCI-H2110	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7116
p.S90I	MV-4-11	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.8453
p.S89I	MV-4-11	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7341
p.R97W	RCC-JF	kidney	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1667
p.S84L	MM1S	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.A78S	KP-1N	pancreas	COSMIC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation rewiring degron network	0.1389
p.A78S	KP-1N	pancreas	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A77S	KP-1N	pancreas	COSMIC	NKENS	DEG_APCC_KENBOX_2	67:71	Mutation substituting flanking lysine	0.2778
p.A77S	KP-1N	pancreas	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation substituting flanking lysine	0.1667
p.S91T	NCI-H2110	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.6005
p.R96W	RCC-JF	kidney	COSMIC	PESSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRG2C

UniProt ID: A6NGY1

Entrez ID: 100288801

Protein name: Protein FRG2-like-2 (FSHD region gene 2 protein family member C) (HSA3-FRG2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRG2C in