DegronMD - Q64ET8(FRG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E93A	TCGA-AP-A1DV	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.R92W	TCGA-D3-A8GO	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2778
p.R98K	TCGA-EE-A2MS	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.R98K	TCGA-EE-A3JA	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.N94Y	TCGA-EO-A22R	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.R98S	TCGA-G2-A3VY	BLCA	TCGA	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.R99S	DO590	BLCA	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation substituting flanking lysine	0.1944
p.S62W	DO225265	BRCA	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.2222
p.S62W	DO228186	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.2222
p.S62W	DO228672	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.2222
p.S62W	DO52357	LUSC	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.2222
p.S62W	DO229250	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.2222
p.S81R	DO52363	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.S81R	DO52357	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.S81R	DO229199	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.S81R	DO229250	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.R99K	DO37567	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation substituting flanking lysine	0.1944
p.R99K	DO47625	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation substituting flanking lysine	0.1944
p.R93W	DO51242	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.G79W	DO229218	THCA	ICGC	NKENS	DEG_APCC_KENBOX_2	66:70	Mutation rewiring degron network	0.0833
p.G79W	DO229218	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.E94A	DO43186	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.N95Y	DO42713	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRG2

UniProt ID: Q64ET8

Entrez ID: 448831

Protein name: Protein FRG2 (FSHD region gene 2 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRG2 in