DegronMD - Q5SYB0(FRMPD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1229K	TCGA-06-5416	GBM	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.0556
p.E1229K	DO10880	GBM	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.0556
p.P1401A	TCGA-23-1022	OV	TCGA	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.0556
p.P1401A	DO31070	OV	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.0556
p.A1407T	TCGA-2G-AAGC	TGCT	TCGA	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.2222
p.P573T	TCGA-39-5034	LUSC	TCGA	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.R839S	TCGA-49-6743	LUAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1111
p.R839S	DO26092	LUAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1111
p.Q849E	TCGA-53-7624	LUAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5633
p.Q849E	DO48433	BLCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5633
p.Q849E	DO25058	LUAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5633
p.S1244T	TCGA-55-8301	LUAD	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6005
p.S1244T	DO24682	LUAD	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6005
p.D1238Y	TCGA-59-2348	OV	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.D1238Y	DO29508	OV	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.D1238Y	SIDM00807	Bladder Carcinoma	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.D1238Y	SIDM01525	Acute Myeloid Leukemia	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.P1254H	TCGA-A5-A0G1	UCEC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.2222
p.P1254H	DO42472	UCEC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.2222
p.P1254H	ACH-001063	Ovarian Cancer	CCLE	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.2222
p.E810D	TCGA-A5-A2K5	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2778
p.E810D	DO41379	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2778
p.R947Q	TCGA-AA-3821	COAD	TCGA	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1944
p.R947Q	DO9314	COAD	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1944
p.R947Q	SIDM01494	Glioblastoma	GDSC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1944
p.R947Q	ACH-000445	Brain Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1944
p.R945H	TCGA-AA-3984	COAD	TCGA	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	TCGA-AP-A1DV	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	TCGA-EO-A3B0	UCEC	TCGA	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	DO222693	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	DO222905	BTCA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	DO9002	COAD	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	DO219773	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945H	DO43186	UCEC	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.K1412N	TCGA-AX-A06F	UCEC	TCGA	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation altering degron motif	0.5806
p.K1412N	DO41752	UCEC	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation altering degron motif	0.5806
p.E586K	TCGA-AX-A2HC	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.E794G	TCGA-B5-A11N	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.E794G	DO41458	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.Y846C	TCGA-BR-8372	STAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation blocking phosphorylation signal	0.75
p.Y846C	DO47873	STAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation blocking phosphorylation signal	0.75
p.D865N	TCGA-BR-8680	STAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1389
p.D865N	TCGA-IB-7651	PAAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1389
p.D865N	DO46657	PAAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1389
p.D865N	DO47769	STAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1389
p.V568E	TCGA-C8-A27B	BRCA	TCGA	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0556
p.E1229Q	TCGA-CN-A6V1	HNSC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.0556
p.E1229Q	DO52048	HNSC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.0556
p.S862C	TCGA-CZ-5460	KIRC	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.2222
p.S862C	DO17226	KIRC	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.2222
p.R838I	TCGA-D1-A17Q	UCEC	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.0833
p.R838I	TCGA-EB-A44O	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.0833
p.R838I	DO47272	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.0833
p.R838I	DO41903	UCEC	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.0833
p.H970D	TCGA-D8-A1J8	BRCA	TCGA	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1944
p.H970D	DO1269	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1944
p.P969L	TCGA-D9-A6EC	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2222
p.P969L	DO50291	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2222
p.S1405F	TCGA-D9-A6EC	SKCM	TCGA	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.1667
p.S1405F	DO50291	SKCM	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.1667
p.P853T	TCGA-DA-A95Z	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5919
p.P853T	DO219481	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5919
p.L1408P	TCGA-DI-A1BU	UCEC	TCGA	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.25
p.L1408P	DO42023	UCEC	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.25
p.D818N	TCGA-DK-A2I4	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.D818N	DO465	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.E794Q	TCGA-DK-AA6L	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.E794Q	DO219002	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.L860M	TCGA-DZ-6133	KIRP	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.2778
p.L860M	DO20762	KIRP	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.2778
p.R1242S	TCGA-E6-A1M0	UCEC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6316
p.R1242S	DO43682	UCEC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6316
p.P809H	TCGA-F1-A448	STAD	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.3056
p.P809H	DO48044	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.3056
p.E954D	TCGA-F5-6814	READ	TCGA	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation altering degron motif	0.6758
p.E954D	DO36556	READ	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation altering degron motif	0.6758
p.E954D	SIDM01611	Endometrial Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation altering degron motif	0.6758
p.E954D	ACH-000996	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation altering degron motif	0.6758
p.P817S	TCGA-FR-A726	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0833
p.P817S	DO48665	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0833
p.P853L	TCGA-FR-A8YC	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.6471
p.P853L	DO50301	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.6471
p.D1238H	TCGA-GS-A9TZ	DLBC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.D1238H	DO219918	DLBC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation rewiring degron network	0.3056
p.D591G	TCGA-K4-A6FZ	BLCA	TCGA	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.D1243Y	TCGA-ND-A4W6	UCS	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6214
p.D865H	DO222955	BTCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1389
p.R1409G	DO223007	ESCA	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.2778
p.S583P	DO223053	ESCA	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.R947W	DO223061	ESCA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1944
p.V1248A	DO233146	GACA	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.6936
p.S1417G	DO233210	GACA	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation altering degron motif	0.5882
p.P960H	DO233855	GACA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.2222
p.P960H	DO233855	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.3056
p.S577N	DO10880	GBM	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.L800F	DO228976	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.R1409I	DO228985	LICA	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.2778
p.R1409I	DO229026	LICA	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.2778
p.R945L	DO229015	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.D818Y	DO229045	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0556
p.V959F	DO229045	LICA	ICGC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.25
p.V959F	DO229045	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2778
p.L578Q	DO26941	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7765
p.P853S	DO222363	MELA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation altering degron motif	0.5641
p.E1427K	DO222749	MELA	ICGC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.0833
p.Y568H	DO232842	NACA	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0556
p.V866M	DO232761	PBCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1111
p.Y587N	DO51315	PRAD	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation blocking phosphorylation signal	0.6389
p.D864E	DO229216	THCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	847:858	Mutation rewiring degron network	0.1667
p.A573T	DO41235	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.R945C	SIDM00234	Other Solid Cancers	GDSC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945C	SIDM01588	Endometrial Carcinoma	GDSC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945C	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945C	ACH-002201	Cervical Cancer	CCLE	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.R945C	TC-YIK	cervix	COSMIC	NKENS	DEG_APCC_KENBOX_2	952:956	Mutation rewiring degron network	0.1389
p.D1243E	SIDM00377	Other Sarcomas	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.5647
p.D1243E	ACH-001655	Endometrial/Uterine Cancer	CCLE	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.5647
p.D1243E	SKN	soft tissue	COSMIC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	1239:1250	Mutation altering degron motif	0.5647
p.A961V	SIDM01117	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00855	Other Sarcomas	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00690	Head and Neck Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00391	Plasma Cell Myeloma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00807	Bladder Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00793	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM01640	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.A961V	SIDM01525	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	961:965	Mutation altering degron motif	0.5825
p.G572D	SIDM00885	Breast Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.G572D	ACH-000111	Breast Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.G572D	HCC1187	breast	COSMIC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.T581K	SIDM00792	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7306
p.T581K	ACH-002170	Lung Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7306
p.T581K	NCI-H1688	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7306
p.Q1424K	SIDM01503	Small Cell Lung Carcinoma	GDSC	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.1667
p.Q1424K	ACH-000844	Lung Cancer	CCLE	LKATPAST	DEG_SCF_FBW7_1	1411:1418	Mutation rewiring degron network	0.1667
p.T581M	ACH-001200	Rhabdoid	CCLE	ASSTT	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMPD1

UniProt ID: Q5SYB0

Entrez ID: 22844

Protein name: FERM and PDZ domain-containing protein 1 (FERM domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FRMPD1 in