DegronMD

Uniprot ID: Q5SYB0

Source protein: FERM and PDZ domain-containing protein 1

Source gene: FRMPD1

Class: DEG_COP1_1

Location: 847:858

E3 ligase: COP1

DEGRON score: 0.5524

ASA_SCORE: 82.4833

COIL: 0.8932

CONS_SCORE: 0.5138

DSS_SCORE: 0.2408

HELIX: 0.0847

FCONS_SCORE: 1.0623

RIG_SCORE: 0.7847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R839S	TCGA-49-6743	LUAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.1111
p.R839S	DO26092	LUAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1111
p.Q849E	TCGA-53-7624	LUAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.5633
p.Q849E	DO48433	BLCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.5633
p.Q849E	DO25058	LUAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.5633
p.Y846C	TCGA-BR-8372	STAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.75
p.Y846C	DO47873	STAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.75
p.D865N	TCGA-BR-8680	STAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.1389
p.D865N	TCGA-IB-7651	PAAD	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.1389
p.D865N	DO46657	PAAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1389
p.D865N	DO47769	STAD	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1389
p.S862C	TCGA-CZ-5460	KIRC	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.2222
p.S862C	DO17226	KIRC	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.2222
p.R838I	TCGA-D1-A17Q	UCEC	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.0833
p.R838I	TCGA-EB-A44O	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.0833
p.R838I	DO47272	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.0833
p.R838I	DO41903	UCEC	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.0833
p.P853T	TCGA-DA-A95Z	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.5919
p.P853T	DO219481	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.5919
p.L860M	TCGA-DZ-6133	KIRP	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.2778
p.L860M	DO20762	KIRP	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.2778
p.P853L	TCGA-FR-A8YC	SKCM	TCGA	TSQVSFPLVPSA	DEG_COP1_1	0.6471
p.P853L	DO50301	SKCM	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.6471
p.D865H	DO222955	BTCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1389
p.P853S	DO222363	MELA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.5641
p.V866M	DO232761	PBCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1111
p.D864E	DO229216	THCA	ICGC	TSQVSFPLVPSA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_COP1_1	847:858	TSQVSFPLVPSA	COP1	0.5524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons