DegronMD

Uniprot ID: Q5SYB0

Source protein: FERM and PDZ domain-containing protein 1

Source gene: FRMPD1

Class: DEG_SCF_FBW7_1

Location: 1411:1418

E3 ligase: FBXW7

DEGRON score: 0.9514

ASA_SCORE: 72

COIL: 0.8506

CONS_SCORE: 0.4383

DSS_SCORE: 0.3344

HELIX: 0.1038

FCONS_SCORE: 0.9983

RIG_SCORE: 0.722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1401A	TCGA-23-1022	OV	TCGA	LKATPAST	DEG_SCF_FBW7_1	0.0556
p.P1401A	DO31070	OV	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.0556
p.A1407T	TCGA-2G-AAGC	TGCT	TCGA	LKATPAST	DEG_SCF_FBW7_1	0.2222
p.K1412N	TCGA-AX-A06F	UCEC	TCGA	LKATPAST	DEG_SCF_FBW7_1	0.5806
p.K1412N	DO41752	UCEC	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.5806
p.S1405F	TCGA-D9-A6EC	SKCM	TCGA	LKATPAST	DEG_SCF_FBW7_1	0.1667
p.S1405F	DO50291	SKCM	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.1667
p.L1408P	TCGA-DI-A1BU	UCEC	TCGA	LKATPAST	DEG_SCF_FBW7_1	0.25
p.L1408P	DO42023	UCEC	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.25
p.R1409G	DO223007	ESCA	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.2778
p.S1417G	DO233210	GACA	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.5882
p.R1409I	DO228985	LICA	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.2778
p.R1409I	DO229026	LICA	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.2778
p.E1427K	DO222749	MELA	ICGC	LKATPAST	DEG_SCF_FBW7_1	0.0833
p.Q1424K	SIDM01503	Small Cell Lung Carcinoma	GDSC	LKATPAST	DEG_SCF_FBW7_1	0.1667
p.Q1424K	ACH-000844	Lung Cancer	CCLE	LKATPAST	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SCF_FBW7_1	1411:1418	LKATPAST	FBXW7	0.9514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons