DegronMD

Uniprot ID: Q5SYB0

Source protein: FERM and PDZ domain-containing protein 1

Source gene: FRMPD1

Class: DEG_ODPH_VHL_1

Location: 1239:1250

E3 ligase: VHL

DEGRON score: 0.9914

ASA_SCORE: 78.8333

COIL: 0.7344

CONS_SCORE: 0.4186

DSS_SCORE: 0.5704

HELIX: 0.0285

FCONS_SCORE: 0.8933

RIG_SCORE: 0.6974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1229K	TCGA-06-5416	GBM	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.0556
p.E1229K	DO10880	GBM	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.0556
p.S1244T	TCGA-55-8301	LUAD	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6005
p.S1244T	DO24682	LUAD	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6005
p.D1238Y	TCGA-59-2348	OV	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.D1238Y	DO29508	OV	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.D1238Y	SIDM00807	Bladder Carcinoma	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.D1238Y	SIDM01525	Acute Myeloid Leukemia	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.P1254H	TCGA-A5-A0G1	UCEC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.2222
p.P1254H	DO42472	UCEC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.2222
p.P1254H	ACH-001063	Ovarian Cancer	CCLE	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.2222
p.E1229Q	TCGA-CN-A6V1	HNSC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.0556
p.E1229Q	DO52048	HNSC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.0556
p.R1242S	TCGA-E6-A1M0	UCEC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6316
p.R1242S	DO43682	UCEC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6316
p.D1238H	TCGA-GS-A9TZ	DLBC	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.D1238H	DO219918	DLBC	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.3056
p.D1243Y	TCGA-ND-A4W6	UCS	TCGA	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6214
p.V1248A	DO233146	GACA	ICGC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.6936
p.D1243E	SIDM00377	Other Sarcomas	GDSC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.5647
p.D1243E	ACH-001655	Endometrial/Uterine Cancer	CCLE	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.5647
p.D1243E	SKN	soft_tissue	COSMIC	IAPRDSPEWVCF	DEG_ODPH_VHL_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_ODPH_VHL_1	1239:1250	IAPRDSPEWVCF	VHL	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons