DegronMD

Uniprot ID: Q49MG5

Source protein: Microtubule-associated protein 9

Source gene: MAP9

Class: DEG_SPOP_SBC_1

Location: 391:395

E3 ligase: SPOP

DEGRON score: 0.8944

ASA_SCORE: 93.46

COIL: 0.9152

CONS_SCORE: 0.4718

DSS_SCORE: 0.625

HELIX: 0.0276

FCONS_SCORE: 0.7773

RIG_SCORE: 0.5911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S386F	TCGA-BR-8679	STAD	TCGA	PSTTT	DEG_SPOP_SBC_1	0.1944
p.S386F	DO47875	STAD	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1944
p.G401R	TCGA-CK-5913	COAD	TCGA	PSTTT	DEG_SPOP_SBC_1	0.1667
p.G401R	DO8826	COAD	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1667
p.K404N	TCGA-EA-A43B	CESC	TCGA	PSTTT	DEG_SPOP_SBC_1	0.1944
p.K404N	DO44384	CESC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.1944
p.S385G	TCGA-UF-A71D	HNSC	TCGA	PSTTT	DEG_SPOP_SBC_1	0.6111
p.S385G	DO52109	HNSC	ICGC	PSTTT	DEG_SPOP_SBC_1	0.6111
p.S397F	DO220823	BRCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7222
p.R389G	DO230311	COCA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.2778
p.P391L	DO222749	MELA	ICGC	PSTTT	DEG_SPOP_SBC_1	0.7582
p.K382N	SIDM00118	Colorectal Carcinoma	GDSC	PSTTT	DEG_SPOP_SBC_1	0.1944
p.K382N	ACH-001081	Colon/Colorectal Cancer	CCLE	PSTTT	DEG_SPOP_SBC_1	0.1944
p.K382N	HCC2998	large_intestine	COSMIC	PSTTT	DEG_SPOP_SBC_1	0.1944
p.L381M	SIDM00720	Mesothelioma	GDSC	PSTTT	DEG_SPOP_SBC_1	0.0556
p.L381M	SIDM01409	Bladder Carcinoma	GDSC	PSTTT	DEG_SPOP_SBC_1	0.0556
p.L381M	NCI-H28	pleura	COSMIC	PSTTT	DEG_SPOP_SBC_1	0.0556
p.Q388L	NCI-SNU-5	stomach	COSMIC	PSTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.7312	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	391:395	PSTTT	SPOP	0.8944	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	584:588	PSTTT	SPOP	0.5391	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	190:194	PSTTT	SPOP	0.8903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons