DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PSTTT
Uniprot ID:
Q9H195
Source protein:
Mucin-3B
Source gene:
MUC3B
Class:
DEG_SPOP_SBC_1
Location:
190:194
E3 ligase:
SPOP
DEGRON score:
0.8903
ASA_SCORE:
89.9
COIL:
0.9386
CONS_SCORE:
0.4322
DSS_SCORE:
0.5832
HELIX:
0.0206
FCONS_SCORE:
0.9883
RIG_SCORE:
0.6857
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q02505
Mucin-3A
DEG_SPOP_SBC_1
190:194
PSTTT
SPOP
0.7312
More...
Q49MG5
Microtubule-associated protein 9
DEG_SPOP_SBC_1
391:395
PSTTT
SPOP
0.8944
More...
Q9H2E6
Semaphorin-6A
DEG_SPOP_SBC_1
584:588
PSTTT
SPOP
0.5391
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
190:194
PSTTT
SPOP
0.8903
More...