DegronMD

Uniprot ID: Q49MG5

Source protein: Microtubule-associated protein 9

Source gene: MAP9

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.9925

ASA_SCORE: 63.84

COIL: 0.6486

CONS_SCORE: 0.7481

DSS_SCORE: 0.5444

HELIX: 0.0754

FCONS_SCORE: 0.9887

RIG_SCORE: 0.8061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S7I	TCGA-A5-A0G1	UCEC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.8453
p.S7I	DO42472	UCEC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.8453
p.A11T	TCGA-FI-A2D5	UCEC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.2778
p.A11T	DO41331	UCEC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.P16A	DO50968	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.1389
p.D3H	SIDM00697	Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.D3H	SIDM00340	Plasma Cell Myeloma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.D3H	SIDM00620	Glioblastoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.D3H	SIDM00648	Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.D3H	SIDM00832	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.D3H	SIDM00854	Burkitt's Lymphoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.I6T	NCI-H128	lung	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.7078
p.D9Y	KYSE-150	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2702:2706	VFSTT	SPOP	0.9768	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	5:9	VFSTT	SPOP	0.9925	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_SPOP_SBC_1	442:446	VFSTT	SPOP	0.5367	More...
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_SPOP_SBC_1	1059:1063	VFSTT	SPOP	0.8676	More...
Q9P2E2	Kinesin-like protein KIF17	DEG_SPOP_SBC_1	500:504	VFSTT	SPOP	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons