DegronMD

Uniprot ID: Q8WWL7

Source protein: G2/mitotic-specific cyclin-B3

Source gene: CCNB3

Class: DEG_SPOP_SBC_1

Location: 1059:1063

E3 ligase: SPOP

DEGRON score: 0.8676

ASA_SCORE: 85.64

COIL: 0.8406

CONS_SCORE: 0.3891

DSS_SCORE: 0.4436

HELIX: 0.0314

FCONS_SCORE: 1.0117

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1055N	TCGA-44-A479	LUAD	TCGA	VFSTT	DEG_SPOP_SBC_1	0.2222
p.T1055N	DO23633	LUAD	ICGC	VFSTT	DEG_SPOP_SBC_1	0.2222
p.L1049F	TCGA-66-2785	LUSC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.0556
p.L1049F	DO26520	LUSC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.0556
p.P1057T	TCGA-EU-5905	KIRC	TCGA	VFSTT	DEG_SPOP_SBC_1	0.2778
p.P1057T	DO18622	KIRC	ICGC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.E1065D	DO228474	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	0.2778
p.IP1050IA	DO222749	MELA	ICGC	VFSTT	DEG_SPOP_SBC_1	0
p.S1056N	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S1056N	ACH-000840	Lung Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	0.25
p.S1056N	HCC-366	lung	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S1071F	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1111
p.S1071F	ACH-002216	Leukemia	CCLE	VFSTT	DEG_SPOP_SBC_1	0.1111
p.S1071F	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.1111
p.E1069D	SIDM00534	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1667
p.E1069D	ACH-000986	Colon/Colorectal Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	0.1667
p.E1069D	HT-115	large_intestine	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.1667
p.S1071Y	ACH-000109	Lung Cancer	CCLE	VFSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2702:2706	VFSTT	SPOP	0.9768	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	5:9	VFSTT	SPOP	0.9925	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_SPOP_SBC_1	442:446	VFSTT	SPOP	0.5367	More...
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_SPOP_SBC_1	1059:1063	VFSTT	SPOP	0.8676	More...
Q9P2E2	Kinesin-like protein KIF17	DEG_SPOP_SBC_1	500:504	VFSTT	SPOP	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons