DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 2702:2706

E3 ligase: SPOP

DEGRON score: 0.9768

ASA_SCORE: 97.7

COIL: 0.913

CONS_SCORE: 0

DSS_SCORE: 0.2878

HELIX: 0.0144

FCONS_SCORE: 0

RIG_SCORE: 0.759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2709Y	SIDM00428	Acute Myeloid Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S2709Y	SIDM00672	Hepatocellular Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S2709Y	SIDM00393	Gastric Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S2709Y	SIDM00118	Colorectal Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.25
p.S2712F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1667
p.S2712F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.1667
p.I2707V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.3056
p.I2707V	HCE-4	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.3056
p.P2711S	SIDM00801	Melanoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1944
p.P2711S	A101D	skin	COSMIC	VFSTT	DEG_SPOP_SBC_1	0.1944
p.S2695P	SIDM00011	Melanoma	GDSC	VFSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2702:2706	VFSTT	SPOP	0.9768	More...
Q49MG5	Microtubule-associated protein 9	DEG_SPOP_SBC_1	5:9	VFSTT	SPOP	0.9925	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_SPOP_SBC_1	442:446	VFSTT	SPOP	0.5367	More...
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_SPOP_SBC_1	1059:1063	VFSTT	SPOP	0.8676	More...
Q9P2E2	Kinesin-like protein KIF17	DEG_SPOP_SBC_1	500:504	VFSTT	SPOP	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons