DegronMD - Q8TEW0(PARD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1258W	TCGA-49-4488	LUAD	TCGA	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.3056
p.S1245F	TCGA-AP-A1DV	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.5556
p.G618R	TCGA-AX-A06F	UCEC	TCGA	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.2222
p.G618R	DO41752	UCEC	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.2222
p.D573Y	TCGA-AZ-4315	COAD	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.25
p.D573Y	DO8842	COAD	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.25
p.S623F	TCGA-BG-A220	UCEC	TCGA	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.0833
p.S623F	DO41784	UCEC	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.0833
p.Y451H	TCGA-CM-5861	COAD	TCGA	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.Y451H	DO7918	COAD	ICGC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.S1261G	TCGA-D1-A163	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.6667
p.D581N	TCGA-D8-A1XJ	BRCA	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.5821
p.D581N	DO5611	BRCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation altering degron motif	0.5821
p.E585K	TCGA-E7-A541	BLCA	TCGA	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.2778
p.E585K	DO44037	BLCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.2778
p.L601F	TCGA-FR-A726	SKCM	TCGA	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.0833
p.L601F	DO48665	SKCM	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.0833
p.A615T	TCGA-MX-A5UJ	STAD	TCGA	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.3056
p.A615T	DO48547	STAD	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.3056
p.S433Y	TCGA-UY-A8OB	BLCA	TCGA	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.0833
p.S433Y	DO219037	BLCA	ICGC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.0833
p.Q1251H	TCGA-ZJ-AAXU	CESC	TCGA	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.2778
p.Y451C	TCGA-ZP-A9D2	LIHC	TCGA	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.Y451C	DO52333	LIHC	ICGC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.Q1248H	DO219759	CESC	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1944
p.N613S	DO7505	CLLE	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation altering degron motif	0.7069
p.E590D	DO227802	COCA	ICGC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.1389
p.G1265S	DO234324	ESAD	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1111
p.T446N	DO229045	LICA	ICGC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7055
p.E1252K	DO45135	LIRI	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.3056
p.R1255W	DO24750	LUAD	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation altering degron motif	0.8634
p.G1265C	DO27532	LUSC	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1111
p.T453N	DO229224	THCA	ICGC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1389
p.S604N	DO231415	THCA	ICGC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation blocking phosphorylation signal	0.6111
p.S1258G	DO41008	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.3056
p.S1265P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1111
p.S1265P	ACH-000914	Lymphoma	CCLE	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1111
p.S1265P	HT	haematopoietic and lymphoid tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1111
p.N452D	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P566L	SIDM00445	Esophageal Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0556
p.P566L	ACH-002292	Esophageal Cancer	CCLE	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0556
p.P566L	OACp4C	oesophagus	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.0556
p.Q1263K	SIDM01045	Endometrial Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1667
p.Q1263K	ACH-000978	Endometrial/Uterine Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1667
p.Q1263K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1667
p.D575N	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.3056
p.D575N	SIDM01582	Gastric Carcinoma	GDSC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.3056
p.G1249S	SIDM01343	Gastric Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.2222
p.R609Q	ACH-001032	Bone Cancer	CCLE	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.3056
p.I619N	CW-2	large intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.1944
p.H622N	CL-34	large intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation substituting flanking lysine	0.2222
p.A617T	SNU-1040	large intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation rewiring degron network	0.25
p.A573T	SNU-1040	large intestine	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.25
p.T604I	RC-K8	haematopoietic and lymphoid tissue	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation blocking phosphorylation signal	0.6111
p.S1249P	HT	haematopoietic and lymphoid tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.2222
p.E1259Q	RH-18	soft tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.7222
p.E1259K	MDA-MB-453	breast	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.7222
p.P1267S	SW684	soft tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.0556
p.H622Y	HT55	large intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation substituting flanking lysine	0.2222
p.E612K	ME-180	cervix	COSMIC	SKENH	DEG_APCC_KENBOX_2	610:614	Mutation altering degron motif	0.7022
p.A454V	TE-9	oesophagus	COSMIC	VFSTT	DEG_SPOP_SBC_1	442:446	Mutation substituting flanking lysine	0.2222
p.S1262P	HT	haematopoietic and lymphoid tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1944
p.Q1259H	DU-145	prostate	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.7222
p.Q1247K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.1667
p.S1266L	Sarc9371	bone	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.0833
p.Q1260K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation blocking phosphorylation signal	0.6944
p.Q1250H	DU-145	prostate	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.25
p.S1252L	Sarc9371	bone	COSMIC	AKENP	DEG_APCC_KENBOX_2	1253:1257	Mutation rewiring degron network	0.3056
p.P587S	SNU-C5	large intestine	COSMIC	IVLTPDGT	DEG_SCF_FBW7_1	576:583	Mutation rewiring degron network	0.2222

Kaplan plot for PARD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARD3

UniProt ID: Q8TEW0

Entrez ID: 56288

Protein name: Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARD3 in