DegronMD

Uniprot ID: Q8TEW0

Source protein: Partitioning defective 3 homolog

Source gene: PARD3

Class: DEG_APCC_KENBOX_2

Location: 610:614

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6221

ASA_SCORE: 98.84

COIL: 0.8806

CONS_SCORE: 0.4609

DSS_SCORE: 0.2802

HELIX: 0.085

FCONS_SCORE: 0.5969

RIG_SCORE: 0.7097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G618R	TCGA-AX-A06F	UCEC	TCGA	SKENH	DEG_APCC_KENBOX_2	0.2222
p.G618R	DO41752	UCEC	ICGC	SKENH	DEG_APCC_KENBOX_2	0.2222
p.S623F	TCGA-BG-A220	UCEC	TCGA	SKENH	DEG_APCC_KENBOX_2	0.0833
p.S623F	DO41784	UCEC	ICGC	SKENH	DEG_APCC_KENBOX_2	0.0833
p.L601F	TCGA-FR-A726	SKCM	TCGA	SKENH	DEG_APCC_KENBOX_2	0.0833
p.L601F	DO48665	SKCM	ICGC	SKENH	DEG_APCC_KENBOX_2	0.0833
p.A615T	TCGA-MX-A5UJ	STAD	TCGA	SKENH	DEG_APCC_KENBOX_2	0.3056
p.A615T	DO48547	STAD	ICGC	SKENH	DEG_APCC_KENBOX_2	0.3056
p.N613S	DO7505	CLLE	ICGC	SKENH	DEG_APCC_KENBOX_2	0.7069
p.S604N	DO231415	THCA	ICGC	SKENH	DEG_APCC_KENBOX_2	0.6111
p.R609Q	ACH-001032	Bone Cancer	CCLE	SKENH	DEG_APCC_KENBOX_2	0.3056
p.I619N	CW-2	large_intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.1944
p.H622N	CL-34	large_intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.2222
p.A617T	SNU-1040	large_intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.25
p.T604I	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.6111
p.H622Y	HT55	large_intestine	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.2222
p.E612K	ME-180	cervix	COSMIC	SKENH	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	610:614	SKENH	APC,CDC20,FZR1	0.6221	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons