DegronMD

Uniprot ID: Q8TEW0

Source protein: Partitioning defective 3 homolog

Source gene: PARD3

Class: DEG_APCC_KENBOX_2

Location: 1253:1257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9045

ASA_SCORE: 90.74

COIL: 0.8642

CONS_SCORE: 0.3398

DSS_SCORE: 0.5888

HELIX: 0.107

FCONS_SCORE: 0.8824

RIG_SCORE: 0.6669

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1258W	TCGA-49-4488	LUAD	TCGA	AKENP	DEG_APCC_KENBOX_2	0.3056
p.S1245F	TCGA-AP-A1DV	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.5556
p.S1261G	TCGA-D1-A163	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.6667
p.Q1251H	TCGA-ZJ-AAXU	CESC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.2778
p.Q1248H	DO219759	CESC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1944
p.G1265S	DO234324	ESAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.E1252K	DO45135	LIRI	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3056
p.R1255W	DO24750	LUAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.8634
p.G1265C	DO27532	LUSC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.S1258G	DO41008	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3056
p.S1265P	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.S1265P	ACH-000914	Lymphoma	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1111
p.S1265P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.Q1263K	SIDM01045	Endometrial Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.Q1263K	ACH-000978	Endometrial/Uterine Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1667
p.Q1263K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.G1249S	SIDM01343	Gastric Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.2222
p.S1249P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.2222
p.E1259Q	RH-18	soft_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.7222
p.E1259K	MDA-MB-453	breast	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.7222
p.P1267S	SW684	soft_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.0556
p.S1262P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1944
p.Q1259H	DU-145	prostate	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.7222
p.Q1247K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.S1266L	Sarc9371	bone	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.Q1260K	EN	endometrium	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.6944
p.Q1250H	DU-145	prostate	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.25
p.S1252L	Sarc9371	bone	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_APCC_KENBOX_2	4:8	AKENP	APC,CDC20,FZR1	0.9545	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	1253:1257	AKENP	APC,CDC20,FZR1	0.9045	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_APCC_KENBOX_2	423:427	AKENP	APC,CDC20,FZR1	0.7516	More...
Q9HDC5	Junctophilin-1	DEG_APCC_KENBOX_2	434:438	AKENP	APC,CDC20,FZR1	0.8024	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_APCC_KENBOX_2	181:185	AKENP	APC,CDC20,FZR1	0.9628	More...
Q96SY0	Integrator complex subunit 14	DEG_APCC_KENBOX_2	375:379	AKENP	APC,CDC20,FZR1	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKENP

Degron related mutations and impact score

Drug responses associated with PARD3 mutations

All proteins holding degron of AKENP