DegronMD

Uniprot ID: Q9Y5T5

Source protein: Ubiquitin carboxyl-terminal hydrolase 16

Source gene: USP16

Class: DEG_APCC_KENBOX_2

Location: 181:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9628

ASA_SCORE: 109.86

COIL: 0.8284

CONS_SCORE: 0.3094

DSS_SCORE: 0.6539

HELIX: 0.1586

FCONS_SCORE: 0.8542

RIG_SCORE: 0.6391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V195M	TCGA-12-5301	GBM	TCGA	AKENP	DEG_APCC_KENBOX_2	0.0556
p.E173D	TCGA-AP-A059	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.1111
p.P185H	TCGA-D1-A17U	UCEC	TCGA	AKENP	DEG_APCC_KENBOX_2	0.6583
p.M187V	TCGA-D7-A6EY	STAD	TCGA	AKENP	DEG_APCC_KENBOX_2	0.2778
p.E178K	TCGA-FS-A1ZQ	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	0.25
p.P185S	TCGA-GF-A6C9	SKCM	TCGA	AKENP	DEG_APCC_KENBOX_2	0.5641
p.G194E	DO234395	ESAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.E174K	DO233619	GACA	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1389
p.V194M	DO11746	GBM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.V194L	DO229034	LICA	ICGC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.Q191E	DO51103	PRAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.E177K	DO37442	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3333
p.P182L	DO47569	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.7582
p.P184S	DO51254	SKCM	ICGC	AKENP	DEG_APCC_KENBOX_2	0.6752
p.M186V	DO50118	STAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.3056
p.N187S	DO50118	STAD	ICGC	AKENP	DEG_APCC_KENBOX_2	0.2778
p.P184H	DO41887	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.7694
p.E172D	DO41361	UCEC	ICGC	AKENP	DEG_APCC_KENBOX_2	0.0833
p.E175D	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.E175D	ACH-000444	Lung Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1667
p.E175D	LU-99A	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1667
p.E173K	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	AKENP	DEG_APCC_KENBOX_2	0.1111
p.E173K	ACH-000726	Esophageal Cancer	CCLE	AKENP	DEG_APCC_KENBOX_2	0.1111
p.E174D	LU-99A	lung	COSMIC	AKENP	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_APCC_KENBOX_2	4:8	AKENP	APC,CDC20,FZR1	0.9545	More...
Q8TEW0	Partitioning defective 3 homolog	DEG_APCC_KENBOX_2	1253:1257	AKENP	APC,CDC20,FZR1	0.9045	More...
Q9H7E2	Tudor domain-containing protein 3	DEG_APCC_KENBOX_2	423:427	AKENP	APC,CDC20,FZR1	0.7516	More...
Q9HDC5	Junctophilin-1	DEG_APCC_KENBOX_2	434:438	AKENP	APC,CDC20,FZR1	0.8024	More...
Q9Y5T5	Ubiquitin carboxyl-terminal hydrolase 16	DEG_APCC_KENBOX_2	181:185	AKENP	APC,CDC20,FZR1	0.9628	More...
Q96SY0	Integrator complex subunit 14	DEG_APCC_KENBOX_2	375:379	AKENP	APC,CDC20,FZR1	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons