DegronMD - Q6WCQ1(MPRIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A657T	TCGA-AZ-4315	COAD	TCGA	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1389
p.R639W	TCGA-B5-A3FC	UCEC	TCGA	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.R639W	TCGA-BG-A222	UCEC	TCGA	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.R639W	SIDM00537	Colorectal Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.R639W	ACH-000982	Colon/Colorectal Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.R639W	ACH-001345	Colon/Colorectal Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.R639W	GP5d	large intestine	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2222
p.V659I	TCGA-DA-A1IC	SKCM	TCGA	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.0833
p.R649L	TCGA-E8-A2EA	THCA	TCGA	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation altering degron motif	0.7316
p.V177A	TCGA-EB-A41A	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5825
p.V177A	DO37429	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5825
p.S187R	DO233245	GACA	ICGC	AVTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1389
p.L641I	DO228934	LICA	ICGC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.2778
p.A14G	DO35083	PACA	ICGC	AKENP	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.1667
p.S189I	DO229221	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.S179T	DO229250	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.6005
p.A657V	SIDM00212	Glioblastoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1389
p.A657V	ACH-000464	Brain Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1389
p.A657V	CAS-1	central nervous system	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1389
p.H660Y	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.0556
p.H660Y	ACH-000916	Lung Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.0556
p.H660Y	NCI-H1573	lung	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.0556
p.Q638R	SIDM01608	Endometrial Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1944
p.Q638R	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation rewiring degron network	0.1944
p.R649W	ACH-000961	Endometrial/Uterine Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	643:650	Mutation altering degron motif	0.7523

Kaplan plot for MPRIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPRIP

UniProt ID: Q6WCQ1

Entrez ID: 23164

Protein name: Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPRIP in