DegronMD

Uniprot ID: Q6WCQ1

Source protein: Myosin phosphatase Rho-interacting protein

Source gene: MPRIP

Class: DEG_SCF_FBW7_2

Location: 643:650

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 99.8625

COIL: 0.7076

CONS_SCORE: 0.5294

DSS_SCORE: 0.5264

HELIX: 0.226

FCONS_SCORE: 1.0892

RIG_SCORE: 0.7635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A657T	TCGA-AZ-4315	COAD	TCGA	VETTPLRE	DEG_SCF_FBW7_2	0.1389
p.R639W	TCGA-B5-A3FC	UCEC	TCGA	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.R639W	TCGA-BG-A222	UCEC	TCGA	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.R639W	SIDM00537	Colorectal Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.R639W	ACH-000982	Colon/Colorectal Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.R639W	ACH-001345	Colon/Colorectal Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.R639W	GP5d	large_intestine	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	0.2222
p.V659I	TCGA-DA-A1IC	SKCM	TCGA	VETTPLRE	DEG_SCF_FBW7_2	0.0833
p.R649L	TCGA-E8-A2EA	THCA	TCGA	VETTPLRE	DEG_SCF_FBW7_2	0.7316
p.L641I	DO228934	LICA	ICGC	VETTPLRE	DEG_SCF_FBW7_2	0.2778
p.A657V	SIDM00212	Glioblastoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	0.1389
p.A657V	ACH-000464	Brain Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.1389
p.A657V	CAS-1	central_nervous_system	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	0.1389
p.H660Y	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	0.0556
p.H660Y	ACH-000916	Lung Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.0556
p.H660Y	NCI-H1573	lung	COSMIC	VETTPLRE	DEG_SCF_FBW7_2	0.0556
p.Q638R	SIDM01608	Endometrial Carcinoma	GDSC	VETTPLRE	DEG_SCF_FBW7_2	0.1944
p.Q638R	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.1944
p.R649W	ACH-000961	Endometrial/Uterine Cancer	CCLE	VETTPLRE	DEG_SCF_FBW7_2	0.7523

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SCF_FBW7_2	643:650	VETTPLRE	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons