DegronMD

Uniprot ID: Q6WCQ1

Source protein: Myosin phosphatase Rho-interacting protein

Source gene: MPRIP

Class: DEG_SPOP_SBC_1

Location: 176:180

E3 ligase: SPOP

DEGRON score: 0.9872

ASA_SCORE: 68.72

COIL: 0.7482

CONS_SCORE: 0.4037

DSS_SCORE: 0.654

HELIX: 0.0316

FCONS_SCORE: 0.9825

RIG_SCORE: 0.6017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V177A	TCGA-EB-A41A	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	0.5825
p.V177A	DO37429	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.5825
p.S187R	DO233245	GACA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.S189I	DO229221	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833
p.S179T	DO229250	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons