DegronMD

Uniprot ID: Q15811

Source protein: Intersectin-1

Source gene: ITSN1

Class: DEG_SPOP_SBC_1

Location: 837:841

E3 ligase: SPOP

DEGRON score: 0.9768

ASA_SCORE: 73.88

COIL: 0.8522

CONS_SCORE: 0.2489

DSS_SCORE: 0.6437

HELIX: 0.0446

FCONS_SCORE: 0.9156

RIG_SCORE: 0.665

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R830C	TCGA-21-1081	LUSC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830C	TCGA-AD-6964	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830C	TCGA-AZ-4315	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830C	DO8842	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830C	DO8360	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830C	DO26930	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.A834V	TCGA-A5-A0G2	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.25
p.A834V	DO41235	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.A851T	TCGA-BH-A18G	BRCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0556
p.A851T	DO3686	BRCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0556
p.P847T	TCGA-D3-A2JC	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1667
p.P847T	DO47578	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.A834T	TCGA-E2-A14T	BRCA	TCGA	AVTSS	DEG_SPOP_SBC_1	0.25
p.A834T	DO5109	BRCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.A828V	TCGA-EO-A22R	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.0833
p.A828V	DO42713	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.0833
p.V838L	TCGA-HP-A5MZ	LIHC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.5654
p.V838L	DO49695	LIHC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.5654
p.R830H	TCGA-HU-A4GU	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R830H	DO47849	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.S841L	SIDM01175	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	0.7667
p.S841L	SW684	soft_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.7667
p.T845M	SIDM00553	Acute Myeloid Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.T845M	SIDM01434	Hepatocellular Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.T845M	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.S840C	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.8652
p.S840C	NCI-H1573	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.8652
p.A837V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.5825
p.S835C	ACH-000916	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.2778
p.S835C	NCI-H1573	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.2778
p.A832V	ACH-000925	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.6389
p.S836L	ACH-002309	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	0.3056
p.S836L	SW684	soft_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.L837F	Mewo	skin	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.6981
p.T840M	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.7423
p.R848K	G-361	skin	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTSS

Degron related mutations and impact score

Drug responses associated with ITSN1 mutations

All proteins holding degron of AVTSS