DegronMD

Uniprot ID: Q5T9C9

Source protein: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Source gene: PIP5KL1

Class: DEG_SPOP_SBC_1

Location: 22:26

E3 ligase: SPOP

DEGRON score: 0.6064

ASA_SCORE: 75.02

COIL: 0.7698

CONS_SCORE: 0.5058

DSS_SCORE: 0.3609

HELIX: 0.1984

FCONS_SCORE: 0.8318

RIG_SCORE: 0.7542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R28W	TCGA-CM-4746	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	0.2778
p.R28W	DO7882	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2778
p.A22S	TCGA-E6-A1LX	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	0.7588
p.A22S	DO41020	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.7588
p.E21K	DO9812	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.R24H	DO48192	ESCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.8244
p.S23R	DO229046	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.7427
p.P30T	DO26987	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.G19E	DO220886	MELA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.25
p.P34S	DO50299	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1111
p.C20Y	DO38487	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	0.2778
p.R33C	DO229253	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.R33C	DO229211	THCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.1389
p.D27N	DO229100	UTCA	ICGC	AVTSS	DEG_SPOP_SBC_1	0.3056
p.A18T	SIDM00664	Pancreatic Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	0.2222
p.R33L	ACH-000916	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	0.1389
p.G32S	EMC-BAC-1	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1667
p.R14K	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_SPOP_SBC_1	329:333	AVTSS	SPOP	0.9756	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	98:102	AVTSS	SPOP	0.9759	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	837:841	AVTSS	SPOP	0.9768	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	917:921	AVTSS	SPOP	0.9878	More...
Q6WCQ1	Myosin phosphatase Rho-interacting protein	DEG_SPOP_SBC_1	176:180	AVTSS	SPOP	0.9872	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	428:432	AVTSS	SPOP	0.9917	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	709:713	AVTSS	SPOP	0.6181	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	41:45	AVTSS	SPOP	0.9578	More...
Q5T9C9	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	DEG_SPOP_SBC_1	22:26	AVTSS	SPOP	0.6064	More...
Q8N5C6	S1 RNA-binding domain-containing protein 1	DEG_SPOP_SBC_1	791:795	AVTSS	SPOP	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons