DegronMD - Q15811(ITSN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R830C	TCGA-21-1081	LUSC	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830C	TCGA-AD-6964	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830C	TCGA-AZ-4315	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830C	DO8842	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830C	DO8360	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830C	DO26930	LUSC	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.I973V	TCGA-50-5939	LUAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	TCGA-EI-6882	READ	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	DO25183	LUAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	DO36531	READ	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	SIDM00845	Burkitt's Lymphoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	SIDM00035	Thyroid Gland Carcinoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.I973V	SIDM01519	Head and Neck Carcinoma	GDSC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1389
p.A834V	TCGA-A5-A0G2	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.25
p.A834V	DO41235	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.25
p.S188C	TCGA-AP-A054	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6667
p.S188C	DO42256	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6667
p.R187S	TCGA-AX-A2HA	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.R187S	DO42504	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.A851T	TCGA-BH-A18G	BRCA	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.0556
p.A851T	DO3686	BRCA	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.0556
p.K975R	TCGA-BR-8687	STAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation substituting flanking lysine	0.3056
p.K975R	DO47801	STAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation substituting flanking lysine	0.3056
p.R310T	TCGA-C5-A1BL	CESC	TCGA	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.R310T	TCGA-C5-A1BL	CESC	TCGA	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1389
p.R310T	DO48986	CESC	ICGC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.R310T	DO48986	CESC	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1389
p.R992Q	TCGA-CK-4951	COAD	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1667
p.R992Q	DO10582	COAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1667
p.S188Y	TCGA-CN-A49A	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6667
p.S188Y	DO52042	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6667
p.P305Q	TCGA-CR-7388	HNSC	TCGA	PPEY	ITCH	300:303	Mutation rewiring degron network	0.2778
p.P305Q	DO14284	HNSC	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.2778
p.S981A	TCGA-D1-A16X	UCEC	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.87
p.S981A	DO41799	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.87
p.P847T	TCGA-D3-A2JC	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1667
p.P847T	DO47578	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1667
p.A176S	TCGA-D3-A2JP	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2222
p.A176S	DO47407	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2222
p.S148C	TCGA-D8-A27G	BRCA	TCGA	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.2778
p.S148C	DO5465	BRCA	ICGC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.2778
p.A834T	TCGA-E2-A14T	BRCA	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.25
p.A834T	DO5109	BRCA	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.25
p.S978I	TCGA-E6-A2P8	UCEC	TCGA	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation blocking phosphorylation signal	0.7222
p.S978I	DO45096	LIRI	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation blocking phosphorylation signal	0.7222
p.S978I	DO40924	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation blocking phosphorylation signal	0.7222
p.P301T	TCGA-EE-A181	SKCM	TCGA	PPEY	ITCH	300:303	Mutation altering degron motif	0.7031
p.P301T	DO37444	SKCM	ICGC	PPEY	ITCH	300:303	Mutation altering degron motif	0.7031
p.P157H	TCGA-EE-A29W	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation altering degron motif	0.7694
p.P157H	DO47658	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation altering degron motif	0.7694
p.A828V	TCGA-EO-A22R	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.0833
p.A828V	DO42713	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.0833
p.P156S	TCGA-ER-A193	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation altering degron motif	0.5641
p.P156S	DO47368	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation altering degron motif	0.5641
p.R310I	TCGA-FS-A1ZN	SKCM	TCGA	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.R310I	TCGA-FS-A1ZN	SKCM	TCGA	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1389
p.R310I	DO38165	SKCM	ICGC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.R310I	DO38165	SKCM	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1389
p.V838L	TCGA-HP-A5MZ	LIHC	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.5654
p.V838L	DO49695	LIHC	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.5654
p.R309I	TCGA-HR-A2OG	SKCM	TCGA	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0556
p.R309I	TCGA-HR-A2OG	SKCM	TCGA	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1667
p.R309I	DO37511	SKCM	ICGC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0556
p.R309I	DO37511	SKCM	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1667
p.R830H	TCGA-HU-A4GU	STAD	TCGA	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R830H	DO47849	STAD	ICGC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.P168L	TCGA-WE-AAA0	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.0556
p.P168L	DO51294	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.0556
p.G980S	DO225287	BRCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.6993
p.G980S	DO227892	BRCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.6993
p.A171V	DO230309	COCA	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0833
p.P972S	DO50336	ESAD	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.1111
p.M290I	DO233121	GACA	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.0556
p.N996D	DO233871	GACA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.0556
p.P306H	DO233865	GACA	ICGC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.25
p.R328M	DO229019	LICA	ICGC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.A162S	DO229006	LICA	ICGC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.2222
p.E332D	DO228221	MALY	ICGC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.H983Y	DO220906	MELA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.7229
p.P970L	DO218874	SKCA	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation blocking phosphorylation signal	0.5
p.P175T	DO229268	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.L987I	DO41758	UCEC	ICGC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.3056
p.S841L	SIDM01175	Other Sarcomas	GDSC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.7667
p.S841L	SW684	soft tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.7667
p.T845M	SIDM00553	Acute Myeloid Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.2222
p.T845M	SIDM01434	Hepatocellular Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.2222
p.T845M	KY821	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.2222
p.L295Q	SIDM00683	Prostate Carcinoma	GDSC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1944
p.L295Q	ACH-000977	lymph node	CCLE	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1944
p.L295Q	LNCaP-Clone-FGC	prostate	COSMIC	PPEY	ITCH	300:303	Mutation rewiring degron network	0.1944
p.R187K	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.R187K	ACH-002264	Esophageal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.R187K	KYSE-50	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.S840C	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.8652
p.S840C	NCI-H1573	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.8652
p.A837V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.5825
p.P330Q	SIDM01658	Unknown	GDSC	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.P330Q	ACH-000598	Myeloma	CCLE	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.D326G	ACH-000398	Lymphoma	CCLE	VISST	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.25
p.V996I	ACH-000750	Skin Cancer	CCLE	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.0556
p.V996I	LOXIMVI	skin	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.0556
p.S835C	ACH-000916	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.2778
p.S835C	NCI-H1573	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.2778
p.A832V	ACH-000925	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation blocking phosphorylation signal	0.6389
p.S836L	ACH-002309	Sarcoma	CCLE	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.3056
p.S836L	SW684	soft tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.3056
p.R318W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VISST	DEG_SPOP_SBC_1	319:323	Mutation blocking phosphorylation signal	0.75
p.Q182R	RKO	large intestine	COSMIC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation altering degron motif	0.7329
p.L837F	Mewo	skin	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.6981
p.T840M	KY821	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation altering degron motif	0.7423
p.R150K	KYSE-50	oesophagus	COSMIC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation altering degron motif	0.7237
p.L179Q	LNCaP-Clone-FGC	prostate	COSMIC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.F163I	HCT-15	large intestine	COSMIC	VPTAAVPPL	DEG_SIAH_1	150:158	Mutation rewiring degron network	0.1944
p.L988V	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.2778
p.L988V	S-117	soft tissue	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation rewiring degron network	0.2778
p.R189M	NCI-H2227	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.H983N	SNU-81	large intestine	COSMIC	DSGSSES	DEG_SCF_TRCP1_1	980:986	Mutation altering degron motif	0.7423
p.R848K	G-361	skin	COSMIC	AVTSS	DEG_SPOP_SBC_1	837:841	Mutation rewiring degron network	0.1389
p.R323C	GP5d	large intestine	COSMIC	VISST	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.8301
p.R189S	CAL-12T	lung	COSMIC	PKSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITSN1

UniProt ID: Q15811

Entrez ID: 6453

Protein name: Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITSN1 in