DegronMD

Uniprot ID: Q15811

Source protein: Intersectin-1

Source gene: ITSN1

Class: DEG_SIAH_1

Location: 150:158

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9815

ASA_SCORE: 76.5444

COIL: 0.9584

CONS_SCORE: 0.3209

DSS_SCORE: 0.307

HELIX: 0.0182

FCONS_SCORE: 0.9699

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S148C	TCGA-D8-A27G	BRCA	TCGA	VPTAAVPPL	DEG_SIAH_1	0.2778
p.S148C	DO5465	BRCA	ICGC	VPTAAVPPL	DEG_SIAH_1	0.2778
p.P157H	TCGA-EE-A29W	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	0.7694
p.P157H	DO47658	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	0.7694
p.P156S	TCGA-ER-A193	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	0.5641
p.P156S	DO47368	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	0.5641
p.P168L	TCGA-WE-AAA0	SKCM	TCGA	VPTAAVPPL	DEG_SIAH_1	0.0556
p.P168L	DO51294	SKCM	ICGC	VPTAAVPPL	DEG_SIAH_1	0.0556
p.A162S	DO229006	LICA	ICGC	VPTAAVPPL	DEG_SIAH_1	0.2222
p.R150K	KYSE-50	oesophagus	COSMIC	VPTAAVPPL	DEG_SIAH_1	0.7237
p.F163I	HCT-15	large_intestine	COSMIC	VPTAAVPPL	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15811	Intersectin-1	DEG_SIAH_1	150:158	VPTAAVPPL	SIAH1,SIAH2,SIAH3	0.9815	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons