DegronMD

Uniprot ID: Q15811

Source protein: Intersectin-1

Source gene: ITSN1

Class: DEG_SPOP_SBC_1

Location: 319:323

E3 ligase: SPOP

DEGRON score: 0.9945

ASA_SCORE: 64.38

COIL: 0.7784

CONS_SCORE: 0.2523

DSS_SCORE: 0.4946

HELIX: 0.0586

FCONS_SCORE: 0.8346

RIG_SCORE: 0.6771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R310T	TCGA-C5-A1BL	CESC	TCGA	VISST	DEG_SPOP_SBC_1	0.0833
p.R310T	DO48986	CESC	ICGC	VISST	DEG_SPOP_SBC_1	0.0833
p.R310I	TCGA-FS-A1ZN	SKCM	TCGA	VISST	DEG_SPOP_SBC_1	0.0833
p.R310I	DO38165	SKCM	ICGC	VISST	DEG_SPOP_SBC_1	0.0833
p.R309I	TCGA-HR-A2OG	SKCM	TCGA	VISST	DEG_SPOP_SBC_1	0.0556
p.R309I	DO37511	SKCM	ICGC	VISST	DEG_SPOP_SBC_1	0.0556
p.R328M	DO229019	LICA	ICGC	VISST	DEG_SPOP_SBC_1	0.1944
p.E332D	DO228221	MALY	ICGC	VISST	DEG_SPOP_SBC_1	0.0833
p.P330Q	SIDM01658	Unknown	GDSC	VISST	DEG_SPOP_SBC_1	0.1389
p.P330Q	ACH-000598	Myeloma	CCLE	VISST	DEG_SPOP_SBC_1	0.1389
p.D326G	ACH-000398	Lymphoma	CCLE	VISST	DEG_SPOP_SBC_1	0.25
p.R318W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VISST	DEG_SPOP_SBC_1	0.75
p.R323C	GP5d	large_intestine	COSMIC	VISST	DEG_SPOP_SBC_1	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons