DegronMD - Q9Y6X9(MORC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R699Q	TCGA-A5-A0G2	UCEC	TCGA	SKSPREVPSP	DEG_COP1_1	703:712	Mutation rewiring degron network	0.2222
p.R699Q	DO41235	UCEC	ICGC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation rewiring degron network	0.2222
p.L638P	TCGA-CK-6746	COAD	TCGA	VISST	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1111
p.L638P	DO7938	COAD	ICGC	VISST	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1111
p.R701T	TCGA-Q9-A6FU	ESCA	TCGA	SKSPREVPSP	DEG_COP1_1	703:712	Mutation rewiring degron network	0.2778
p.P648S	TCGA-ZJ-A8QR	CESC	TCGA	VISST	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6752
p.P648S	DO219749	CESC	ICGC	VISST	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6752
p.R645Q	DO228955	LICA	ICGC	VISST	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.D710E	DO229034	LICA	ICGC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.6758
p.S703C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.8652
p.S703C	ACH-002238	Leukemia	CCLE	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.8652
p.S703C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.8652
p.E708D	SIDM00530	Esophageal Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.5647
p.E708D	SIDM00821	Kidney Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.5647
p.E708D	ACH-001544	Esophageal Cancer	CCLE	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.5647
p.E708D	KYAE-1	oesophagus	COSMIC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.5647
p.K721N	SIDM00875	Breast Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation substituting flanking lysine	0.1944
p.K721N	ACH-000624	Breast Cancer	CCLE	SKSPREVPSP	DEG_COP1_1	703:712	Mutation substituting flanking lysine	0.1944
p.K721N	HCC1806	breast	COSMIC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation substituting flanking lysine	0.1944
p.T650I	ACH-001310	Non-Cancerous	CCLE	VISST	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.8189
p.S641C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VISST	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.K659N	HCC1806	breast	COSMIC	VISST	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0833
p.D710N	HT-1376	urinary tract	COSMIC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.6932
p.E707K	HT-1376	urinary tract	COSMIC	SKSPREVPSP	DEG_COP1_1	703:712	Mutation altering degron motif	0.7022
p.E646D	KYAE-1	oesophagus	COSMIC	VISST	DEG_SPOP_SBC_1	646:650	Mutation altering degron motif	0.6758

Kaplan plot for MORC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MORC2

UniProt ID: Q9Y6X9

Entrez ID: 22880

Protein name: ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MORC2 in