DegronMD

Uniprot ID: Q9Y6X9

Source protein: ATPase MORC2

Source gene: MORC2

Class: DEG_COP1_1

Location: 703:712

E3 ligase: COP1

DEGRON score: 0.9973

ASA_SCORE: 104.17

COIL: 0.945

CONS_SCORE: 0.4671

DSS_SCORE: 0.6077

HELIX: 0.0249

FCONS_SCORE: 1.1206

RIG_SCORE: 0.5989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R699Q	TCGA-A5-A0G2	UCEC	TCGA	SKSPREVPSP	DEG_COP1_1	0.2222
p.R699Q	DO41235	UCEC	ICGC	SKSPREVPSP	DEG_COP1_1	0.2222
p.R701T	TCGA-Q9-A6FU	ESCA	TCGA	SKSPREVPSP	DEG_COP1_1	0.2778
p.D710E	DO229034	LICA	ICGC	SKSPREVPSP	DEG_COP1_1	0.6758
p.S703C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SKSPREVPSP	DEG_COP1_1	0.8652
p.S703C	ACH-002238	Leukemia	CCLE	SKSPREVPSP	DEG_COP1_1	0.8652
p.S703C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SKSPREVPSP	DEG_COP1_1	0.8652
p.E708D	SIDM00530	Esophageal Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	0.5647
p.E708D	SIDM00821	Kidney Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	0.5647
p.E708D	ACH-001544	Esophageal Cancer	CCLE	SKSPREVPSP	DEG_COP1_1	0.5647
p.E708D	KYAE-1	oesophagus	COSMIC	SKSPREVPSP	DEG_COP1_1	0.5647
p.K721N	SIDM00875	Breast Carcinoma	GDSC	SKSPREVPSP	DEG_COP1_1	0.1944
p.K721N	ACH-000624	Breast Cancer	CCLE	SKSPREVPSP	DEG_COP1_1	0.1944
p.K721N	HCC1806	breast	COSMIC	SKSPREVPSP	DEG_COP1_1	0.1944
p.D710N	HT-1376	urinary_tract	COSMIC	SKSPREVPSP	DEG_COP1_1	0.6932
p.E707K	HT-1376	urinary_tract	COSMIC	SKSPREVPSP	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6X9	ATPase MORC2	DEG_COP1_1	703:712	SKSPREVPSP	COP1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons