DegronMD

Uniprot ID: Q9Y6X9

Source protein: ATPase MORC2

Source gene: MORC2

Class: DEG_SPOP_SBC_1

Location: 646:650

E3 ligase: SPOP

DEGRON score: 0.9775

ASA_SCORE: 94

COIL: 0.9422

CONS_SCORE: 0.2424

DSS_SCORE: 0.6545

HELIX: 0.0202

FCONS_SCORE: 0.8552

RIG_SCORE: 0.6348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L638P	TCGA-CK-6746	COAD	TCGA	VISST	DEG_SPOP_SBC_1	0.1111
p.L638P	DO7938	COAD	ICGC	VISST	DEG_SPOP_SBC_1	0.1111
p.P648S	TCGA-ZJ-A8QR	CESC	TCGA	VISST	DEG_SPOP_SBC_1	0.6752
p.P648S	DO219749	CESC	ICGC	VISST	DEG_SPOP_SBC_1	0.6752
p.R645Q	DO228955	LICA	ICGC	VISST	DEG_SPOP_SBC_1	0.3056
p.T650I	ACH-001310	Non-Cancerous	CCLE	VISST	DEG_SPOP_SBC_1	0.8189
p.S641C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VISST	DEG_SPOP_SBC_1	0.1944
p.K659N	HCC1806	breast	COSMIC	VISST	DEG_SPOP_SBC_1	0.0833
p.E646D	KYAE-1	oesophagus	COSMIC	VISST	DEG_SPOP_SBC_1	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons