DegronMD

Uniprot ID: O75445

Source protein: Usherin

Source gene: USH2A

Class: DEG_SPOP_SBC_1

Location: 4745:4749

E3 ligase: SPOP

DEGRON score: 0.9055

ASA_SCORE: 49.8

COIL: 0.603

CONS_SCORE: 0

DSS_SCORE: 0.2644

HELIX: 0.0088

FCONS_SCORE: 0

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H4744Q	TCGA-21-1076	LUSC	TCGA	VISST	DEG_SPOP_SBC_1	0.3056
p.H4744Q	DO26599	LUSC	ICGC	VISST	DEG_SPOP_SBC_1	0.3056
p.T4742R	TCGA-55-A4DG	LUAD	TCGA	VISST	DEG_SPOP_SBC_1	0.25
p.T4742R	DO26337	LUAD	ICGC	VISST	DEG_SPOP_SBC_1	0.25
p.P4735T	TCGA-63-5128	LUSC	TCGA	VISST	DEG_SPOP_SBC_1	0.0556
p.P4735T	DO27255	LUSC	ICGC	VISST	DEG_SPOP_SBC_1	0.0556
p.V4753I	TCGA-AP-A051	UCEC	TCGA	VISST	DEG_SPOP_SBC_1	0.2222
p.V4753I	DO42673	UCEC	ICGC	VISST	DEG_SPOP_SBC_1	0.2222
p.E4736K	TCGA-D7-6527	STAD	TCGA	VISST	DEG_SPOP_SBC_1	0.0833
p.E4736K	DO38635	STAD	ICGC	VISST	DEG_SPOP_SBC_1	0.0833
p.G4759R	ACH-001057	Lymphoma	CCLE	VISST	DEG_SPOP_SBC_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons