DegronMD - O75445(USH2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H4744Q	TCGA-21-1076	LUSC	TCGA	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.3056
p.H4744Q	DO26599	LUSC	ICGC	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.3056
p.G1919S	TCGA-22-5473	LUSC	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2778
p.G1919S	DO26467	LUSC	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2778
p.G1911R	TCGA-23-1022	OV	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.G1911R	TCGA-KD-A5QT	SARC	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.G1911R	DO31070	OV	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.G1911R	DO223271	SARC	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.G1911R	DO219871	SKCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.E4707Q	TCGA-37-4135	LUSC	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6744
p.E4707Q	DO26806	LUSC	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6744
p.R5076I	TCGA-44-3918	LUAD	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.8102
p.R5076I	DO23732	LUAD	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.8102
p.T4742R	TCGA-55-A4DG	LUAD	TCGA	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.25
p.T4742R	DO26337	LUAD	ICGC	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.25
p.Y1929C	TCGA-5M-AAT6	COAD	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.25
p.Y1929C	DO223703	COAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.25
p.P4735T	TCGA-63-5128	LUSC	TCGA	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.0556
p.P4735T	DO27255	LUSC	ICGC	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.0556
p.F4697S	TCGA-66-2758	LUSC	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.1944
p.F4697S	DO26731	LUSC	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.1944
p.R1930L	TCGA-69-7764	LUAD	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.R1930L	TCGA-D3-A2JC	SKCM	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.R1930L	DO24626	LUAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.R1930L	DO47578	SKCM	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.T1925I	TCGA-94-8490	LUSC	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.7078
p.T1925I	DO52021	LUSC	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.7078
p.R1930Q	TCGA-A5-A0G2	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.R1930Q	DO41235	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.2222
p.S4696Y	TCGA-AA-A010	COAD	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.1667
p.V4753I	TCGA-AP-A051	UCEC	TCGA	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.2222
p.V4753I	DO42673	UCEC	ICGC	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.2222
p.E4701K	TCGA-AR-A0U2	BRCA	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	TCGA-DU-6392	LGG	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	TCGA-EO-A22X	UCEC	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	DO5067	BRCA	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	DO22237	LGG	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	DO43907	UCEC	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	SIDM00394	Cervical Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	SIDM01012	Other Blood Cancers	GDSC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	ACH-000346	Leukemia	CCLE	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	ACH-001650	Cervical Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	JVM-3	haematopoietic and lymphoid tissue	COSMIC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E4701K	SISO	cervix	COSMIC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.3056
p.E5075K	TCGA-D3-A8GI	SKCM	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.591
p.E5075K	DO220851	MELA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.591
p.E5075K	DO50284	SKCM	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.591
p.E4736K	TCGA-D7-6527	STAD	TCGA	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.0833
p.E4736K	DO38635	STAD	ICGC	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.0833
p.Q1922K	TCGA-DJ-A2QB	THCA	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.5833
p.Q1922K	DO39421	THCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.5833
p.P4704H	TCGA-EO-A22R	UCEC	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.7694
p.P4704H	DO42713	UCEC	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.7694
p.G1911E	TCGA-EO-A3B0	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.G1911E	DO219773	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.S4700F	TCGA-FS-A4F0	SKCM	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.2778
p.S4700F	DO37891	SKCM	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.2778
p.R5065K	TCGA-FW-A3R5	SKCM	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.0556
p.R5065K	DO37406	SKCM	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.0556
p.P4704L	TCGA-FW-A3R5	SKCM	TCGA	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6471
p.P4704L	DO37406	SKCM	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6471
p.N5090H	TCGA-MH-A854	KIRP	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.1389
p.N5090H	DO49773	KIRP	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.1389
p.S5087F	TCGA-MT-A51X	HNSC	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation blocking phosphorylation signal	0.6667
p.S5087F	DO44441	HNSC	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation blocking phosphorylation signal	0.6667
p.E1918K	TCGA-N8-A4PL	UCS	TCGA	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.25
p.R5076T	TCGA-ZF-AA4V	BLCA	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.7876
p.R5076T	DO219087	BLCA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.7876
p.R5076T	DO46390	OV	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.7876
p.G4692R	DO227990	COCA	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.0556
p.T4706K	DO229027	LICA	ICGC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6195
p.P5093Q	DO229026	LICA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.0556
p.E1936D	DO52674	MALY	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.0556
p.P1923A	DO50708	ORCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.7503
p.P1923L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6471
p.P1923L	ACH-002263	Esophageal Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6471
p.P1923L	KYSE-220	oesophagus	COSMIC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6471
p.L5079F	SIDM00789	Colorectal Carcinoma	GDSC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.6981
p.L5079F	ACH-000997	Colon/Colorectal Cancer	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.6981
p.L5079F	ACH-001061	Colon/Colorectal Cancer	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.6981
p.L5079F	HCT-15	large intestine	COSMIC	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation altering degron motif	0.6981
p.F1924L	SIDM00899	Pancreatic Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6981
p.F1924L	ACH-000222	Pancreatic Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6981
p.F1924L	AsPC-1	pancreas	COSMIC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation altering degron motif	0.6981
p.I1932M	SIDM00333	Endometrial Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.1667
p.I1932M	ACH-000988	Endometrial/Uterine Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.1667
p.I1932M	MFE-319	endometrium	COSMIC	LQPFTE	LIG_APCC_ABBA_1	1921:1926	Mutation rewiring degron network	0.1667
p.I4698K	SIDM00537	Colorectal Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.2222
p.I4698K	ACH-001345	Colon/Colorectal Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.2222
p.I4698K	GP5d	large intestine	COSMIC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.2222
p.L4703S	SIDM00543	Melanoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6556
p.L4703S	ACH-002120	Skin Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6556
p.L4703S	GAK	skin	COSMIC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation altering degron motif	0.6556
p.W4713L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.1667
p.W4713L	KYSE-150	oesophagus	COSMIC	LLPFTE	LIG_APCC_ABBA_1	4702:4707	Mutation rewiring degron network	0.1667
p.E5070K	ACH-000122	Leukemia	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	5075:5083	Mutation rewiring degron network	0.1944
p.G4759R	ACH-001057	Lymphoma	CCLE	VISST	DEG_SPOP_SBC_1	4745:4749	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USH2A

UniProt ID: O75445

Entrez ID: 7399

Protein name: Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USH2A in