DegronMD

Uniprot ID: O75445

Source protein: Usherin

Source gene: USH2A

Class: LIG_APCC_ABBA_1

Location: 4702:4707

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7887

ASA_SCORE: 59.0667

COIL: 0.7257

CONS_SCORE: 0

DSS_SCORE: 0.0961

HELIX: 0.0152

FCONS_SCORE: 0

RIG_SCORE: 0.8738

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4707Q	TCGA-37-4135	LUSC	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.6744
p.E4707Q	DO26806	LUSC	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.6744
p.F4697S	TCGA-66-2758	LUSC	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.1944
p.F4697S	DO26731	LUSC	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.1944
p.S4696Y	TCGA-AA-A010	COAD	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.1667
p.E4701K	TCGA-AR-A0U2	BRCA	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	TCGA-DU-6392	LGG	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	TCGA-EO-A22X	UCEC	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	DO5067	BRCA	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	DO22237	LGG	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	DO43907	UCEC	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	SIDM00394	Cervical Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	SIDM01012	Other Blood Cancers	GDSC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	ACH-000346	Leukemia	CCLE	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	ACH-001650	Cervical Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.E4701K	SISO	cervix	COSMIC	LLPFTE	LIG_APCC_ABBA_1	0.3056
p.P4704H	TCGA-EO-A22R	UCEC	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.7694
p.P4704H	DO42713	UCEC	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.7694
p.S4700F	TCGA-FS-A4F0	SKCM	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.2778
p.S4700F	DO37891	SKCM	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.2778
p.P4704L	TCGA-FW-A3R5	SKCM	TCGA	LLPFTE	LIG_APCC_ABBA_1	0.6471
p.P4704L	DO37406	SKCM	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.6471
p.G4692R	DO227990	COCA	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.0556
p.T4706K	DO229027	LICA	ICGC	LLPFTE	LIG_APCC_ABBA_1	0.6195
p.I4698K	SIDM00537	Colorectal Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	0.2222
p.I4698K	ACH-001345	Colon/Colorectal Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	0.2222
p.I4698K	GP5d	large_intestine	COSMIC	LLPFTE	LIG_APCC_ABBA_1	0.2222
p.L4703S	SIDM00543	Melanoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	0.6556
p.L4703S	ACH-002120	Skin Cancer	CCLE	LLPFTE	LIG_APCC_ABBA_1	0.6556
p.L4703S	GAK	skin	COSMIC	LLPFTE	LIG_APCC_ABBA_1	0.6556
p.W4713L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LLPFTE	LIG_APCC_ABBA_1	0.1667
p.W4713L	KYSE-150	oesophagus	COSMIC	LLPFTE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLPFTE

Degron related mutations and impact score

Drug responses associated with USH2A mutations

All proteins holding degron of LLPFTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75445	Usherin	LIG_APCC_ABBA_1	4702:4707	LLPFTE	APC,CDC20,FZR1	0.7887	More...