DegronMD

Uniprot ID: O75445

Source protein: Usherin

Source gene: USH2A

Class: DEG_APCC_DBOX_1

Location: 5075:5083

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9508

ASA_SCORE: 108.3778

COIL: 0.9577

CONS_SCORE: 0

DSS_SCORE: 0.3582

HELIX: 0.0243

FCONS_SCORE: 0

RIG_SCORE: 0.76

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5076I	TCGA-44-3918	LUAD	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.8102
p.R5076I	DO23732	LUAD	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.8102
p.E5075K	TCGA-D3-A8GI	SKCM	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.591
p.E5075K	DO220851	MELA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.591
p.E5075K	DO50284	SKCM	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.591
p.R5065K	TCGA-FW-A3R5	SKCM	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.0556
p.R5065K	DO37406	SKCM	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.0556
p.N5090H	TCGA-MH-A854	KIRP	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.1389
p.N5090H	DO49773	KIRP	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.1389
p.S5087F	TCGA-MT-A51X	HNSC	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6667
p.S5087F	DO44441	HNSC	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6667
p.R5076T	TCGA-ZF-AA4V	BLCA	TCGA	ERPPLVPLQ	DEG_APCC_DBOX_1	0.7876
p.R5076T	DO219087	BLCA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.7876
p.R5076T	DO46390	OV	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.7876
p.P5093Q	DO229026	LICA	ICGC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.0556
p.L5079F	SIDM00789	Colorectal Carcinoma	GDSC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6981
p.L5079F	ACH-000997	Colon/Colorectal Cancer	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6981
p.L5079F	ACH-001061	Colon/Colorectal Cancer	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6981
p.L5079F	HCT-15	large_intestine	COSMIC	ERPPLVPLQ	DEG_APCC_DBOX_1	0.6981
p.E5070K	ACH-000122	Leukemia	CCLE	ERPPLVPLQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75445	Usherin	DEG_APCC_DBOX_1	5075:5083	ERPPLVPLQ	APC,CDC20,FZR1	0.9508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons