DegronMD

Uniprot ID: O75445

Source protein: Usherin

Source gene: USH2A

Class: LIG_APCC_ABBA_1

Location: 1921:1926

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8471

ASA_SCORE: 58.4667

COIL: 0.7177

CONS_SCORE: 0

DSS_SCORE: 0.1456

HELIX: 0.0117

FCONS_SCORE: 0

RIG_SCORE: 0.8563

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1919S	TCGA-22-5473	LUSC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.2778
p.G1919S	DO26467	LUSC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.2778
p.G1911R	TCGA-23-1022	OV	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.G1911R	TCGA-KD-A5QT	SARC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.G1911R	DO31070	OV	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.G1911R	DO223271	SARC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.G1911R	DO219871	SKCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.Y1929C	TCGA-5M-AAT6	COAD	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.25
p.Y1929C	DO223703	COAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.25
p.R1930L	TCGA-69-7764	LUAD	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.R1930L	TCGA-D3-A2JC	SKCM	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.R1930L	DO24626	LUAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.R1930L	DO47578	SKCM	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.T1925I	TCGA-94-8490	LUSC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.7078
p.T1925I	DO52021	LUSC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.7078
p.R1930Q	TCGA-A5-A0G2	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.R1930Q	DO41235	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.2222
p.Q1922K	TCGA-DJ-A2QB	THCA	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.5833
p.Q1922K	DO39421	THCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.5833
p.G1911E	TCGA-EO-A3B0	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.G1911E	DO219773	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.E1918K	TCGA-N8-A4PL	UCS	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.25
p.E1936D	DO52674	MALY	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.0556
p.P1923A	DO50708	ORCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.7503
p.P1923L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	0.6471
p.P1923L	ACH-002263	Esophageal Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.6471
p.P1923L	KYSE-220	oesophagus	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.6471
p.F1924L	SIDM00899	Pancreatic Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	0.6981
p.F1924L	ACH-000222	Pancreatic Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.6981
p.F1924L	AsPC-1	pancreas	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.6981
p.I1932M	SIDM00333	Endometrial Carcinoma	GDSC	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.I1932M	ACH-000988	Endometrial/Uterine Cancer	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.I1932M	MFE-319	endometrium	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75445	Usherin	LIG_APCC_ABBA_1	1921:1926	LQPFTE	APC,CDC20,FZR1	0.8471	More...
Q8NI17	Interleukin-31 receptor subunit alpha	LIG_APCC_ABBA_1	191:196	LQPFTE	APC,CDC20,FZR1	0.7504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQPFTE

Degron related mutations and impact score

Drug responses associated with USH2A mutations

All proteins holding degron of LQPFTE