DegronMD

Uniprot ID: Q8NI17

Source protein: Interleukin-31 receptor subunit alpha

Source gene: IL31RA

Class: LIG_APCC_ABBA_1

Location: 191:196

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7504

ASA_SCORE: 58.0833

COIL: 0.7407

CONS_SCORE: 0.9214

DSS_SCORE: 0.0974

HELIX: 0.0078

FCONS_SCORE: 1.3823

RIG_SCORE: 0.9013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P183L	TCGA-AP-A059	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.1111
p.P183L	DO41361	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.1111
p.R193L	TCGA-B5-A0JY	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.8428
p.R193L	DO43041	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.8428
p.A182V	TCGA-D8-A27N	BRCA	TCGA	LQPFTE	LIG_APCC_ABBA_1	0.1944
p.A182V	DO3892	BRCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.1944
p.A189T	DO9876	COAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.2778
p.K193R	DO227802	COCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.7237
p.V186A	DO233634	GACA	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.1944
p.R192H	DO13605	GBM	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.8244
p.R192H	DO47781	STAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.8244
p.Y199C	DO10880	GBM	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.25
p.Y199C	DO47867	STAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.25
p.Y199C	DO42033	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.25
p.T202M	DO41572	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.V197D	SIDM00087	Plasma Cell Myeloma	GDSC	LQPFTE	LIG_APCC_ABBA_1	0.3056
p.V197D	ACH-000817	Myeloma	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.3056
p.S185L	SIDM01159	Other Sarcomas	GDSC	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.S185L	ACH-002310	Liposarcoma	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.S185L	SW872	soft_tissue	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.1667
p.V205A	ACH-000920	Leukemia	CCLE	LQPFTE	LIG_APCC_ABBA_1	0.0833
p.R192S	NCI-H524	lung	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.7427
p.S197Y	SNU-81	large_intestine	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.3056
p.A204V	SU-DHL-8	NS	COSMIC	LQPFTE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75445	Usherin	LIG_APCC_ABBA_1	1921:1926	LQPFTE	APC,CDC20,FZR1	0.8471	More...
Q8NI17	Interleukin-31 receptor subunit alpha	LIG_APCC_ABBA_1	191:196	LQPFTE	APC,CDC20,FZR1	0.7504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons