DegronMD - Q8NI17(IL31RA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K158N	TCGA-AG-A002	READ	TCGA	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.P183L	TCGA-AP-A059	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1111
p.P183L	DO41361	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1111
p.R193L	TCGA-B5-A0JY	UCEC	TCGA	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.8428
p.R193L	DO43041	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.8428
p.F160V	TCGA-B5-A11E	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.F160V	DO41644	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.P156Q	TCGA-D3-A3C6	SKCM	TCGA	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.A182V	TCGA-D8-A27N	BRCA	TCGA	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation substituting flanking lysine	0.1944
p.A182V	DO3892	BRCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation substituting flanking lysine	0.1944
p.R161H	TCGA-FG-6692	LGG	TCGA	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.R161H	DO22307	LGG	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.K169I	TCGA-RC-A6M4	LIHC	TCGA	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7531
p.A189T	DO9876	COAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.2778
p.K193R	DO227802	COCA	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.7237
p.V186A	DO233634	GACA	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1944
p.R192H	DO13605	GBM	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.8244
p.R192H	DO47781	STAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.8244
p.Y199C	DO10880	GBM	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.25
p.Y199C	DO47867	STAD	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.25
p.Y199C	DO42033	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.25
p.L166F	DO229034	LICA	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6981
p.R170Q	DO220886	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.R170Q	DO232761	PBCA	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.3056
p.S166L	DO220906	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7667
p.S166L	SW872	soft tissue	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7667
p.P160S	DO229234	THCA	ICGC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.T202M	DO41572	UCEC	ICGC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1667
p.V197D	SIDM00087	Plasma Cell Myeloma	GDSC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.3056
p.V197D	ACH-000817	Myeloma	CCLE	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.3056
p.R161S	SIDM00282	Colorectal Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.R161S	ACH-000998	Colon/Colorectal Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.R161S	CW-2	large intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.I168M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7618
p.I168M	H513	pleura	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7618
p.S185L	SIDM01159	Other Sarcomas	GDSC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1667
p.S185L	ACH-002310	Liposarcoma	CCLE	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1667
p.S185L	SW872	soft tissue	COSMIC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1667
p.W176C	SIDM00901	Endometrial Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.W176C	ACH-000940	Endometrial/Uterine Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.W176C	AN3-CA	endometrium	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.P157A	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2222
p.P157A	ACH-000912	Lung Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2222
p.V205A	ACH-000920	Leukemia	CCLE	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.0833
p.R192S	NCI-H524	lung	COSMIC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation altering degron motif	0.7427
p.R179S	NCI-H524	lung	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.S197Y	SNU-81	large intestine	COSMIC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.3056
p.W157C	AN3-CA	endometrium	COSMIC	VNSTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2222
p.A204V	SU-DHL-8	NS	COSMIC	LQPFTE	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.1111

Kaplan plot for IL31RA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL31RA

UniProt ID: Q8NI17

Entrez ID: 133396

Protein name: Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL31RA in