DegronMD

Uniprot ID: Q8NI17

Source protein: Interleukin-31 receptor subunit alpha

Source gene: IL31RA

Class: DEG_SPOP_SBC_1

Location: 165:169

E3 ligase: SPOP

DEGRON score: 0.8554

ASA_SCORE: 83.94

COIL: 0.92

CONS_SCORE: 0.8493

DSS_SCORE: 0.1292

HELIX: 0.0092

FCONS_SCORE: 1.2118

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K158N	TCGA-AG-A002	READ	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1389
p.F160V	TCGA-B5-A11E	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1944
p.F160V	DO41644	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1944
p.P156Q	TCGA-D3-A3C6	SKCM	TCGA	VNSTS	DEG_SPOP_SBC_1	0.0833
p.R161H	TCGA-FG-6692	LGG	TCGA	VNSTS	DEG_SPOP_SBC_1	0.2222
p.R161H	DO22307	LGG	ICGC	VNSTS	DEG_SPOP_SBC_1	0.2222
p.K169I	TCGA-RC-A6M4	LIHC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.7531
p.L166F	DO229034	LICA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.6981
p.R170Q	DO220886	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.R170Q	DO232761	PBCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.S166L	DO220906	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.7667
p.S166L	SW872	soft_tissue	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.7667
p.P160S	DO229234	THCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1944
p.R161S	SIDM00282	Colorectal Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.2222
p.R161S	ACH-000998	Colon/Colorectal Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.2222
p.R161S	CW-2	large_intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.2222
p.I168M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.7618
p.I168M	H513	pleura	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.7618
p.W176C	SIDM00901	Endometrial Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.1389
p.W176C	ACH-000940	Endometrial/Uterine Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.1389
p.W176C	AN3-CA	endometrium	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.1389
p.P157A	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.2222
p.P157A	ACH-000912	Lung Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.2222
p.R179S	NCI-H524	lung	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.W157C	AN3-CA	endometrium	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SPOP_SBC_1	723:727	VNSTS	SPOP	0.6245	More...
Q8NI17	Interleukin-31 receptor subunit alpha	DEG_SPOP_SBC_1	165:169	VNSTS	SPOP	0.8554	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	821:825	VNSTS	SPOP	0.8426	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	817:821	VNSTS	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons