DegronMD - Q9UPP5(KIAA1107)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D822N	TCGA-EO-A22X	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.6932
p.A753V	TCGA-F5-6814	READ	TCGA	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.S821F	TCGA-PK-A5HB	ACC	TCGA	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation altering degron motif	0.7982
p.R747T	DO5333	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.S828Y	DO222421	BTCA	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.S828Y	DO7783	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.S828Y	DO7801	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.S828Y	DO43682	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.N827H	DO222637	BTCA	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.2778
p.S820L	DO8730	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.3056
p.S755I	DO52478	COCA	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.G746V	DO229029	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7532
p.G733R	DO50970	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.S828F	DO222837	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.S828F	DO41572	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	821:825	Mutation rewiring degron network	0.25
p.Q744K	DO219774	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.6944
p.I756S	DO42472	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0556

Kaplan plot for KIAA1107 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1107

UniProt ID: Q9UPP5

Entrez ID: 284697

Protein name: AP2-interacting clathrin-endocytosis protein (APache)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1107 in