DegronMD

Uniprot ID: Q9UPP5

Source protein: AP2-interacting clathrin-endocytosis protein

Source gene: KIAA1107

Class: DEG_SPOP_SBC_1

Location: 821:825

E3 ligase: SPOP

DEGRON score: 0.8426

ASA_SCORE: 88.42

COIL: 0.8992

CONS_SCORE: 0.3369

DSS_SCORE: 0.5313

HELIX: 0.0682

FCONS_SCORE: 0.8077

RIG_SCORE: 0.7193

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D822N	TCGA-EO-A22X	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.6932
p.S821F	TCGA-PK-A5HB	ACC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.7982
p.S828Y	DO222421	BTCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.S828Y	DO7783	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.S828Y	DO7801	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.S828Y	DO43682	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.N827H	DO222637	BTCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.2778
p.S820L	DO8730	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.S828F	DO222837	MELA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.S828F	DO41572	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SPOP_SBC_1	723:727	VNSTS	SPOP	0.6245	More...
Q8NI17	Interleukin-31 receptor subunit alpha	DEG_SPOP_SBC_1	165:169	VNSTS	SPOP	0.8554	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	821:825	VNSTS	SPOP	0.8426	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	817:821	VNSTS	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons