DegronMD

Uniprot ID: P23468

Source protein: Receptor-type tyrosine-protein phosphatase delta

Source gene: PTPRD

Class: DEG_SPOP_SBC_1

Location: 723:727

E3 ligase: SPOP

DEGRON score: 0.6245

ASA_SCORE: 59.58

COIL: 0.5474

CONS_SCORE: 0.738

DSS_SCORE: 0.4168

HELIX: 0.0072

FCONS_SCORE: 1.1454

RIG_SCORE: 0.7253

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E719Q	TCGA-17-Z031	LUAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.2222
p.E719Q	SIDM01291	Esophageal Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.2222
p.R733H	TCGA-44-7670	LUAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1667
p.W732C	TCGA-6A-AB49	LUSC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1944
p.W732C	DO52020	LUSC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1944
p.P737T	TCGA-99-8028	LUAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.0556
p.S727Y	TCGA-A5-A0G1	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.712
p.K717N	TCGA-D1-A0ZO	UCEC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.2778
p.V728G	TCGA-EE-A2A2	SKCM	TCGA	VNSTS	DEG_SPOP_SBC_1	0.3056
p.R716H	TCGA-F1-6874	STAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1389
p.R716H	TCGA-GV-A3JX	BLCA	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1389
p.P714S	TCGA-FW-A3R5	SKCM	TCGA	VNSTS	DEG_SPOP_SBC_1	0.0833
p.E721Q	TCGA-LC-A66R	BLCA	TCGA	VNSTS	DEG_SPOP_SBC_1	0.2778
p.S725T	TCGA-Q1-A6DT	CESC	TCGA	VNSTS	DEG_SPOP_SBC_1	0.6005
p.E721D	TCGA-XK-AAIW	PRAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.2778
p.R737H	DO51951	BLCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.R737H	DO48902	PBCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.R737H	SNU-1040	large_intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.E724K	DO737	BLCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.7022
p.Q727E	DO225196	BRCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.6744
p.K726Q	DO8288	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.6944
p.E716G	DO234230	ESAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1389
p.Q730H	DO223072	ESCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.N725I	DO223071	ESCA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.728
p.L733F	DO14254	HNSC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1667
p.I728M	DO20762	KIRP	ICGC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.I730F	DO22237	LGG	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.H728N	DO229029	LICA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.Q730K	DO229032	LICA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.P724T	DO229009	LICA	ICGC	VNSTS	DEG_SPOP_SBC_1	0.7031
p.P724T	DO23561	LUAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.7031
p.L733S	DO229098	LMS	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1667
p.G729C	DO25574	LUAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.2778
p.G733V	DO24692	LUAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1667
p.R720H	DO23555	LUAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.25
p.G725C	DO37090	READ	ICGC	VNSTS	DEG_SPOP_SBC_1	0.76
p.R737S	DO37631	SKCM	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.V715G	DO37583	SKCM	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1111
p.K737N	DO51738	STAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.K737N	RKN	ovary	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.V734M	DO51738	STAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1389
p.Q713K	DO47985	STAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0556
p.K724N	DO43723	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.6918
p.S714Y	DO42472	UCEC	ICGC	VNSTS	DEG_SPOP_SBC_1	0.0833
p.A722S	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.A722S	SIDM00441	Acute Myeloid Leukemia	GDSC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.V723I	SIDM00282	Colorectal Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.7076
p.V723I	ACH-000998	Colon/Colorectal Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.7076
p.V723I	CW-2	large_intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.7076
p.V730D	ACH-000662	Lung Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.25
p.V723A	ACH-001991	Primary	CCLE	VNSTS	DEG_SPOP_SBC_1	0.5825
p.K734N	RKN	ovary	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.1389
p.K727N	RKN	ovary	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.6918
p.K732N	RKN	ovary	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.1944
p.R735H	SNU-1040	large_intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.1111
p.R730H	SNU-1040	large_intestine	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SPOP_SBC_1	723:727	VNSTS	SPOP	0.6245	More...
Q8NI17	Interleukin-31 receptor subunit alpha	DEG_SPOP_SBC_1	165:169	VNSTS	SPOP	0.8554	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	821:825	VNSTS	SPOP	0.8426	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	817:821	VNSTS	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNSTS

Degron related mutations and impact score

Drug responses associated with PTPRD mutations

All proteins holding degron of VNSTS