DegronMD

Uniprot ID: Q9ULK2

Source protein: Ataxin-7-like protein 1

Source gene: ATXN7L1

Class: DEG_SPOP_SBC_1

Location: 817:821

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 84.42

COIL: 0.9154

CONS_SCORE: 0.3738

DSS_SCORE: 0.6466

HELIX: 0.0574

FCONS_SCORE: 1.0953

RIG_SCORE: 0.6338

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A811T	TCGA-AY-6197	COAD	TCGA	VNSTS	DEG_SPOP_SBC_1	0.1667
p.A811T	DO9956	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	0.1667
p.A811T	ACH-000799	Skin Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.1667
p.P816L	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	0.3056
p.P816L	ACH-002264	Esophageal Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	0.3056
p.P816L	KYSE-50	oesophagus	COSMIC	VNSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SPOP_SBC_1	723:727	VNSTS	SPOP	0.6245	More...
Q8NI17	Interleukin-31 receptor subunit alpha	DEG_SPOP_SBC_1	165:169	VNSTS	SPOP	0.8554	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	821:825	VNSTS	SPOP	0.8426	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	817:821	VNSTS	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons