DegronMD - Q9ULK2(ATXN7L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K35E	TCGA-34-5239	LUSC	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.591
p.K35E	DO27660	LUSC	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.591
p.S231L	TCGA-AN-A0XU	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	TCGA-B5-A1MR	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	DO1712	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	DO41758	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.K22R	TCGA-AP-A1DK	UCEC	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation substituting flanking lysine	0.1944
p.K22R	DO42033	UCEC	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation substituting flanking lysine	0.1944
p.Q24H	TCGA-AX-A0J0	UCEC	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.1389
p.Q24H	DO41133	UCEC	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.1389
p.A811T	TCGA-AY-6197	COAD	TCGA	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.1667
p.A811T	DO9956	COAD	ICGC	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.1667
p.A811T	ACH-000799	Skin Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.1667
p.R34S	TCGA-BR-A4QL	STAD	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.6316
p.R34S	DO38723	STAD	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.6316
p.P46L	TCGA-D3-A5GU	SKCM	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.1389
p.P46L	DO47584	SKCM	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.1389
p.S232P	TCGA-EO-A22X	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.S232P	DO43907	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.3056
p.S650L	TCGA-EY-A1G8	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.S650L	DO43578	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.S650L	SIDM00217	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.L43V	TCGA-XF-A8HD	BLCA	TCGA	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.L43V	DO49795	BLCA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.G134R	DO10068	COAD	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation blocking phosphorylation signal	0.6389
p.H154Y	DO227745	COCA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.1389
p.H154Y	DO227745	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2222
p.S236C	DO50342	ESAD	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.1944
p.D143N	DO233152	GACA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.6932
p.V235I	DO233652	GACA	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.2222
p.K22N	DO233777	GACA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation substituting flanking lysine	0.1944
p.E142V	DO228278	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7693
p.D637Y	DO228896	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.Q139K	DO228974	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.6944
p.A165D	DO229018	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.25
p.H144N	DO229019	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7423
p.P46T	DO229034	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.1389
p.A41E	DO229034	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2778
p.P39T	DO229036	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7031
p.L32M	DO229008	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.5999
p.S48P	DO48701	LIRI	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.0833
p.L153V	DO230937	LUSC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.1667
p.L153V	DO230937	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1944
p.R139S	DO231022	LUSC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7427
p.P130L	DO220877	MELA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.0833
p.V36M	DO46556	OV	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7208
p.P647S	DO35442	PACA	ICGC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.6752
p.S641I	DO51180	PAEN	ICGC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation blocking phosphorylation signal	0.6111
p.P157S	DO36556	READ	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.0556
p.P157S	DO36556	READ	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.S162Y	DO50075	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.712
p.F146L	DO43154	UCEC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.6981
p.D33H	SIDM00845	Burkitt's Lymphoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM00461	Acute Myeloid Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM01519	Head and Neck Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	ACH-000786	Lymphoma	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	Daudi	haematopoietic and lymphoid tissue	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.R27T	SIDM00845	Burkitt's Lymphoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	SIDM00461	Acute Myeloid Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	SIDM01519	Head and Neck Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	ACH-000786	Lymphoma	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	ACH-000992	Head and Neck Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.R27T	Daudi	haematopoietic and lymphoid tissue	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222
p.D637N	SIDM00210	Ovarian Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.D637N	A2780	ovary	COSMIC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.F42L	SIDM01118	Small Cell Lung Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.25
p.F42L	ACH-002175	Lung Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.25
p.F42L	NCI-H740	lung	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.25
p.P816L	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.3056
p.P816L	ACH-002264	Esophageal Cancer	CCLE	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.3056
p.P816L	KYSE-50	oesophagus	COSMIC	VNSTS	DEG_SPOP_SBC_1	817:821	Mutation rewiring degron network	0.3056
p.N218K	SIDM00826	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0833
p.N218K	SIDM00870	Breast Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0833
p.P39A	SIDM00954	Breast Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.6392
p.P39A	ACH-001820	Breast Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.6392
p.P39A	COLO-824	breast	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.6392
p.S661F	ACH-000882	Skin Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.S649Y	ACH-000946	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8231
p.N138K	ACH-001551	Skin Cancer	CCLE	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation rewiring degron network	0.3056
p.T167M	ACH-001793	Liposarcoma	CCLE	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1944
p.I139V	EFO-27	ovary	COSMIC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7076
p.S661Y	PL-21	haematopoietic and lymphoid tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.Y40C	23132-87	stomach	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.3056
p.T234M	LNZTA3WT4	central nervous system	COSMIC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.25
p.A217P	CP66-MEL	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0556
p.S659L	SW684	soft tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.1111
p.K655R	LS-180	large intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation blocking phosphorylation signal	0.6667
p.S661P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation rewiring degron network	0.0556
p.H43R	KYSE-70	oesophagus	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN7L1

UniProt ID: Q9ULK2

Entrez ID: 222255

Protein name: Ataxin-7-like protein 1 (Ataxin-7-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN7L1 in