DegronMD - Q9ULK2(ATXN7L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S650L	TCGA-EY-A1G8	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.S650L	DO43578	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.S650L	SIDM00217	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8778
p.S649Y	ACH-000946	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	647:651	Mutation altering degron motif	0.8231
p.E142V	DO228278	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7693
p.D33H	SIDM00845	Burkitt's Lymphoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM00461	Acute Myeloid Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	SIDM01519	Head and Neck Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	ACH-000786	Lymphoma	CCLE	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.D33H	Daudi	haematopoietic and lymphoid tissue	COSMIC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7688
p.S231L	TCGA-AN-A0XU	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	TCGA-B5-A1MR	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	DO1712	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.S231L	DO41758	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.7667
p.R139S	DO231022	LUSC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7427
p.H144N	DO229019	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7423
p.V36M	DO46556	OV	ICGC	TLDRKVPSP	DEG_COP1_1	31:39	Mutation altering degron motif	0.7208
p.S162Y	DO50075	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.712
p.I139V	EFO-27	ovary	COSMIC	PRTSLVQVK	DEG_APCC_DBOX_1	139:147	Mutation altering degron motif	0.7076

Showing 1 to 20 of 91 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN7L1

UniProt ID: Q9ULK2

Entrez ID: 222255

Protein name: Ataxin-7-like protein 1 (Ataxin-7-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN7L1 in